STAT3 signaling is activated in human skeletal muscle following acute resistance exercise

Show simple item record Trenerry, MK en Carey, KA en Ward, AC en Cameron-Smith, David en
dc.coverage.spatial United States en 2012-03-22T00:23:05Z en 2007 en
dc.identifier.citation Journal of Applied Physiology 102(4):1483-1489 2007 en
dc.identifier.issn 8750-7587 en
dc.identifier.uri en
dc.description.abstract Trenerry MK, Carey KA, Ward AC, Cameron-Smith D. STAT3 signaling is activated in human skeletal muscle following acute resistance exercise. J Appl Physiol 102: 1483–1489, 2007. First published January 4, 2007; doi:10.1152/japplphysiol.01147.2006.— The transcription factor signal transducer and activator of transcription 3 (STAT3) has been identified as a mediator of cytokine signaling and implicated in hypertrophy; however, the importance of this pathway following resistance exercise in human skeletal muscle has not been investigated. In the present study, the phosphorylation and nuclear localization of STAT3, together with STAT3-regulated genes, were measured in the early recovery period following intense resistance exercise. Muscle biopsy samples from healthy subjects (7 males, 23.0 0.9 yr) were harvested before and again at 2, 4, and 24 h into recovery following a single bout of maximal leg extension exercise (3 sets, 12 repetitions). Rapid and transient activation of phosphorylated (tyrosine 705) STAT3 was observed at 2 h postexercise. STAT3 phosphorylation paralleled the transient localization of STAT3 to the nucleus, which also peaked at 2 h postexercise. Downstream transcriptional events regulated by STAT3 activation peaked at 2 h postexercise, including early responsive genes c-FOS (800-fold), JUNB (38-fold), and c-MYC (140-fold) at 2 h postexercise. A delayed peak in VEGF (4-fold) was measured 4 h postexercise. Finally, genes associated with modulating STAT3 signaling were also increased following exercise, including the negative regulator SOCS3 (60-fold). Thus, following a single bout of intense resistance exercise, a rapid phosphorylation and nuclear translocation of STAT3 are evident in human skeletal muscle. These data suggest that STAT3 signaling is an important common element and may contribute to the remodeling and adaptation of skeletal muscle following resistance exercise. en
dc.language eng en
dc.publisher the American Physiological Society en
dc.relation.ispartofseries Journal of Applied Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Adaptation, Physiological en
dc.subject Adult en
dc.subject Exercise en
dc.subject Humans en
dc.subject Male en
dc.subject Muscle, Skeletal en
dc.subject Phosphorylation en
dc.subject Physical Endurance en
dc.subject Physical Exertion en
dc.subject STAT3 Transcription Factor en
dc.subject Signal Transduction en
dc.title STAT3 signaling is activated in human skeletal muscle following acute resistance exercise en
dc.type Journal Article en
dc.identifier.doi 10.1152/japplphysiol.01147.2006 en
pubs.issue 4 en
pubs.begin-page 1483 en
pubs.volume 102 en
dc.rights.holder Copyright: The American Physiological Society en
dc.identifier.pmid 17204573 en
pubs.end-page 1489 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 225425 en
dc.identifier.eissn 1522-1601 en
pubs.record-created-at-source-date 2012-03-30 en
pubs.dimensions-id 17204573 en

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