dc.contributor.author |
Wake, GC |
en |
dc.contributor.author |
Pleasants, AB |
en |
dc.contributor.author |
Vickers, Mark |
en |
dc.contributor.author |
Sheppard, Allan |
en |
dc.contributor.author |
Gluckman, Peter |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2012-03-22T19:58:32Z |
en |
dc.date.issued |
2011-01 |
en |
dc.identifier.citation |
Mathematical Biosciences 229(1):109-114 Jan 2011 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/15114 |
en |
dc.description.abstract |
A dynamical model describing the glucose-insulin physiological system was applied to an experiment on the administration of the adipokine leptin between neonatal days 3 and 13 to rats whose dams were subject to different levels of nutrition during gestation. The effect of leptin treatment on the glucose-insulin equilibrium point and on the levels of other associated metabolites showed a significant change in direction that depended on the level of prenatal nutrition. Leptin has been shown to affect two factors that affect the equilibrium levels of glucose and insulin, gluconeogenesis and insulin sensitivity. Each effect is described by a parameter in the dynamical model. Mathematical analysis shows that changes in these parameters in the manner promoted by leptin would indeed increase or decrease the glucose-insulin equilibria depending on their initial equilibrium levels which might be induced by the level of prenatal nutrition. This analysis explains the results of the leptin experiment in the context of the dynamics of the glucocorticoid system. It also proposes a physiological mechanism for the expression of plasticity in the organism based on the status of the glucose and insulin equilibria. |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Mathematical Biosciences |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0025-5564/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Algorithms |
en |
dc.subject |
Animals |
en |
dc.subject |
Animals, Newborn |
en |
dc.subject |
Blood Glucose |
en |
dc.subject |
Female |
en |
dc.subject |
Gluconeogenesis |
en |
dc.subject |
Insulin |
en |
dc.subject |
Insulin Resistance |
en |
dc.subject |
Insulin-Secreting Cells |
en |
dc.subject |
Leptin |
en |
dc.subject |
Malnutrition |
en |
dc.subject |
Maternal Nutritional Physiological Phenomena |
en |
dc.subject |
Models, Biological |
en |
dc.subject |
Pregnancy |
en |
dc.subject |
Prenatal Exposure Delayed Effects |
en |
dc.subject |
Rats |
en |
dc.title |
The application of a model of glucose and insulin dynamics to explain an observed effect of leptin administration in reversal of developmental programming. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.mbs.2010.11.005 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
109 |
en |
pubs.volume |
229 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
21129387 |
en |
pubs.end-page |
114 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
197607 |
en |
pubs.org-id |
Liggins Institute |
en |
dc.identifier.eissn |
1879-3134 |
en |
dc.identifier.pii |
S0025-5564(10)00178-1 |
en |
pubs.record-created-at-source-date |
2012-03-23 |
en |
pubs.dimensions-id |
21129387 |
en |