Vaccine injection technique and reactogenicity--evidence for practice.

Show simple item record Petousis-Harris, Helen en
dc.coverage.spatial Netherlands en 2012-03-22T20:42:40Z en 2008-11-25 en
dc.identifier.citation Vaccine 26(50):6299-6304 25 Nov 2008 en
dc.identifier.issn 0264-410X en
dc.identifier.uri en
dc.description.abstract There are inconsistencies in recommendations and practice with regards to how best to administer vaccines. This review evaluates the literature on intramuscular vaccine administration technique in primarily paediatric populations and concludes from available evidence which aspects of vaccine administration are associated with reactogenicity. Variables with best evidence to support practice to reduce reactogenicity were: Site of injection--less reactogenicity has been noted when the buttock is used rather than the thigh; tissue (muscle or subcutaneous)--less reactions are noted when vaccine is administered intramuscularly rather than subcutaneously; length of needle--longer needles are associated with less reactogenicity. Angle of injection--a 90 degrees angle is associated with less reactogenicity than a reduced angle. Despite a need for more empirical studies, there appears to be several vaccine administration techniques relating to needle angle, length, site and depth of injection that result in fewer reactions and these could be considered for public health policy, in conjunction with immunogenicity. en
dc.language eng en
dc.publisher Elsevier en
dc.relation.ispartofseries Vaccine en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Child en
dc.subject Child, Preschool en
dc.subject Humans en
dc.subject Infant en
dc.subject Injections, Intramuscular en
dc.subject Injections, Subcutaneous en
dc.subject Vaccination en
dc.subject Vaccines en
dc.title Vaccine injection technique and reactogenicity--evidence for practice. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.vaccine.2008.08.052 en
pubs.issue 50 en
pubs.begin-page 6299 en
pubs.volume 26 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 18804137 en
pubs.end-page 6304 en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 303056 en Medical and Health Sciences en Population Health en Gen.Practice& Primary Hlthcare en
dc.identifier.pii S0264-410X(08)01201-2 en
pubs.record-created-at-source-date 2012-03-23 en
pubs.dimensions-id 18804137 en

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