dc.contributor.author |
Craig, Jennifer |
en |
dc.contributor.author |
Purslow, C |
en |
dc.contributor.author |
Murphy, PJ |
en |
dc.contributor.author |
Wolffsohn, JS |
en |
dc.date.accessioned |
2012-03-25T20:13:14Z |
en |
dc.date.issued |
2010-01-21 |
en |
dc.identifier.citation |
Cont Lens Anterior Eye 33(2):83-87 Apr 2010 |
en |
dc.identifier.issn |
1367-0484 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/15197 |
en |
dc.description.abstract |
PURPOSE: With the potential to address evaporative dry eye, a novel spray has been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study evaluated the short-term effects of liposomal spray application on the lipid and stability characteristics of the pre-ocular tear film in normal eyes. METHODS: Twenty-two subjects (12M, 10F) aged 35.1+/-7.1 years participated in this prospective, randomised, double-masked investigation in which the liposomal spray was applied to one eye, and an equal volume of saline spray (control) applied to the contralateral eye. Lipid layer grade (LLG), non-invasive tear film stability (NIBUT) and tear meniscus height (TMH) were evaluated at baseline, and at 30, 60, 90 and 135min post-application. Subjective reports of comfort were also compared. RESULTS: Treated and control eyes were not significantly different at baseline (p>0.05). Post-application, LLG increased significantly, at 30 and 60min, only in the treated eyes (p=0.005). NIBUT also increased significantly in the treated eyes only (p<0.001), at 30, 60 and 90min. TMH did not alter significantly (p>0.05). Comfort improved relative to baseline in 46% of treated and 18% of control eyes, at 30min post-application. Of those expressing a preference in comfort between the eyes, 68% preferred the liposomal spray. CONCLUSIONS: Consistent with subjective reports of improved comfort, statistically and clinically significant improvements in lipid layer thickness and tear film stability are observed in normal eyes for > or =1h after a single application of a phospholipid liposomal spray. |
en |
dc.language |
English |
en |
dc.publisher |
Elsevier Ltd.; British Contact Lens Association |
en |
dc.relation.ispartofseries |
Cont Lens Anterior Eye |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
Details obtained from http://www.sherpa.ac.uk/romeo/issn/1367-0484/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Effect of a liposomal spray on the pre-ocular tear film |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.clae.2009.12.007 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
83 |
en |
pubs.volume |
33 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd.; British Contact Lens Association |
en |
dc.identifier.pmid |
20096622 |
en |
pubs.end-page |
87 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
97338 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Ophthalmology Department |
en |
pubs.record-created-at-source-date |
2010-12-02 |
en |
pubs.dimensions-id |
20096622 |
en |