Systematic review: Nutritional support in acute pancreatitis

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dc.contributor.author Petrov, Maxim en
dc.contributor.author Pylypchuk, Romana en
dc.contributor.author Emelyanov, NV en
dc.date.accessioned 2012-03-25T20:30:21Z en
dc.date.issued 2008 en
dc.identifier.citation Alimentary Pharmacology and Therapeutics 28(6):704-712 2008 en
dc.identifier.issn 0269-2813 en
dc.identifier.uri http://hdl.handle.net/2292/15208 en
dc.description.abstract Aim:  To perform a systematic review of the data from randomized controlled trials (RCTs) in acute pancreatitis that compares enteral nutrition with no supplementary nutrition, parenteral nutrition with no supplementary nutrition and enteral nutrition with parenteral nutrition. Methods  A search was undertaken in the MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials. Results  Fifteen RCTs were included. Enteral nutrition, when compared with no supplementary nutrition, was associated with no significant change in infectious complications: ratio of relative risks (RR) 0.56, 95% confidence interval (CI) 0.07–4.32, P = 0.58, but a significant reduction in mortality: ratio of RR 0.22, 95% CI 0.07–0.70, P = 0.01. Parenteral nutrition, when compared with no supplementary nutrition, was associated with no significant change in infectious complications: RR 1.36, 95% CI 0.18–10.40; P = 0.77, but a significant reduction in mortality: RR 0.36, 95% CI 0.13–0.97, P = 0.04. Enteral nutrition, when compared with parenteral nutrition, was associated with a significant reduction in infectious complications: RR 0.41, 95% CI 0.30–0.57, P < 0.001, but no significant change in mortality: RR 0.60, 95% CI 0.32–1.14, P = 0.12. Conclusions  The use of either enteral or parenteral nutrition, in comparison with no supplementary nutrition, is associated with a lower risk of death in acute pancreatitis. Enteral nutrition is associated with a lower risk of infectious complications compared with parenteral nutrition. en
dc.publisher Blackwell Publishing en
dc.relation.ispartofseries Alimentary Pharmacology and Therapeutics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0269-2813/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Systematic review: Nutritional support in acute pancreatitis en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1365-2036.2008.03786.x en
pubs.issue 6 en
pubs.begin-page 704 en
pubs.volume 28 en
dc.rights.holder Copyright: Blackwell Publishing en
dc.identifier.pmid 19145726 en
pubs.end-page 712 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 143046 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Epidemiology & Biostatistics en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
dc.identifier.eissn 1365-2036 en
pubs.record-created-at-source-date 2012-03-26 en
pubs.dimensions-id 19145726 en


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