The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism

Show simple item record Naot, Dorit en Cornish, Jillian en 2012-03-26T02:06:01Z en 2008 en
dc.identifier.citation BONE 43(5):813-818 01 Nov 2008 en
dc.identifier.issn 8756-3282 en
dc.identifier.uri en
dc.description.abstract The ‘calcitonin family’ is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedullin 2 (intermedin). These hormones are produced by different tissues, with calcitonin being produced in thyroid C cells, αCGRP predominantly in neural tissue, amylin in β-islet cells of the pancreas and adrenomedullin in many tissues and cell types. Bone appears to be a common target for all the peptides of the calcitonin family, although the specific bone effects of the peptides vary. Administration of calcitonin produces rapid lowering of serum calcium levels, mainly through inhibition of bone resorption by osteoclasts. In vitro and in a number of animal experimental models, amylin and CGRP are also effective in inhibiting osteoclast activity and bone resorption. Amylin, adrenomedullin and CGRP can also affect cells of the osteoblast lineage, inducing osteoblast proliferation and promoting bone formation. Receptors for the peptides of the calcitonin family are formed by heterodimerization of the calcitonin receptor (CTR) or calcitonin receptor-like receptor (CLR) with receptor activity modifying proteins (RAMPs). Although the different combinations of these proteins create receptors with distinct ligand specificities, there is a degree of cross-reactivity and the receptors are able to bind other ligands from the family, usually with lower affinity. Analysis of the expression of the receptors for the calcitonin family in 16 samples of human osteoblasts showed high levels of CLR and RAMP1, low levels of RAMP2 and no expression of RAMP3 or CTR. Recent studies of the bone phenotype of knockout animals lacking the calcitonin, αCGRP or amylin gene indicated that in this experimental system the main physiological role of amylin in bone is the inhibition of bone resorption, that of CGRP is the activation of bone formation, while calcitonin, unexpectedly appears to be inhibiting bone formation without affecting bone resorption. Further investigations will be required to determine the mechanisms of action of calcitonin peptides in bone and their significance to human bone physiology. en
dc.publisher Elsevier and International Bone and Mineral Society en
dc.relation.ispartofseries Bone en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.bone.2008.07.003 en
pubs.issue 5 en
pubs.begin-page 813 en
pubs.volume 43 en
dc.rights.holder Copyright: Elsevier and International Bone and Mineral Society en
dc.identifier.pmid 18687416 en
pubs.end-page 818 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 81903 en Medical and Health Sciences en School of Medicine en Medicine Department en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18687416 en

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