Independence of Restrictive Filling Pattern and LV Ejection Fraction with Mortality in Heart Failure: An Individual Patient Meta-Analysis.

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Show simple item record Whalley, Gillian en Doughty, Robert en Poppe, Katrina en Gamble, Gregory en Dini, FL en Moller, JE en Klein, AL en Quintana, M en Yu, CM en 2012-03-26T02:31:00Z en 2008 en
dc.identifier.citation EUROPEAN JOURNAL OF HEART FAILURE 10(8):786-792 2008 en
dc.identifier.issn 1388-9842 en
dc.identifier.uri en
dc.description.abstract Background: The Doppler echocardiographic restrictive mitral filling pattern (RFP) is an important prognostic indicator in patients with heart failure (HF), but the interaction between RFP, left ventricular ejection fraction (LVEF) and filling pattern remains uncertain. Aims: To determine whether the RFP is predictive of mortality independently of LVEF in patients with HF. Methods: Online databases were searched to identify studies assessing the relationship between prognosis and LV filling pattern in patients with HF. Individual patient data from 18 studies (3540 patients) were extracted and collated at the MeRGE Coordinating Centre (The University of Auckland). Results: Overall, RFP was associated with higher all-cause mortality than the non-restrictive filling pattern: hazard ratio 2.42 (95% CI 2.06, 2.83). In multivariable analysis the RFP, LVEF, NYHA class and age were independent predictors of mortality. The prevalence of the RFP was inversely related to LVEF but remained a predictor of mortality even in those patients with preserved LVEF. Conclusions: The restrictive mitral filling pattern is a powerful predictor of mortality, independent of LVEF and age, in patients with HF. Doppler-derived LV filling patterns are an accessible marker from echocardiography that can readily be incorporated in risk stratification of all patients with HF. en
dc.publisher European Society of Cardiology en
dc.relation.ispartofseries European Journal of Heart Failure en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Independence of Restrictive Filling Pattern and LV Ejection Fraction with Mortality in Heart Failure: An Individual Patient Meta-Analysis. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ejheart.2008.06.005 en
pubs.issue 8 en
pubs.begin-page 786 en
pubs.volume 10 en
dc.rights.holder Copyright: European Society of Cardiology en
dc.identifier.pmid 18617438 en
pubs.end-page 792 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 83766 en Medical and Health Sciences en Population Health en Epidemiology & Biostatistics en School of Medicine en Medicine Department en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18617438 en

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