Different prognostic relevance of left ventricular volumes and ejection fraction in heart failure patients with ischernic or non ischemic aetiology: A meta analysis

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dc.contributor.author Ghio, S en
dc.contributor.author Temporelli, PL en
dc.contributor.author Marsan, NA en
dc.contributor.author Poppe, Katrina en
dc.contributor.author Doughty, Robert en
dc.contributor.author Giannuzzi, P en
dc.contributor.author Tavazzi, L en
dc.contributor.author Whalley, G en
dc.date.accessioned 2012-03-26T02:31:23Z en
dc.date.issued 2007-06-01 en
dc.identifier.citation EUROPEAN JOURNAL OF HEART FAILURE 6(Suppl):51-51 01 Jun 2007 en
dc.identifier.issn 1388-9842 en
dc.identifier.uri http://hdl.handle.net/2292/15370 en
dc.description.abstract Background: A reduced left ventricular (LV) ejection fraction (EF) is considered an indicator of poor prognosis in heart failure (HF) patients. However, the predictive power of other commonly used echocardiographic indicators such as a restrictive LV filling pattern (RFP), enddiastolic (EDV) and end-systolic (ESV) LV volumes is still incompletely defined. Aim. The aim of this analysis was to assess the prognostic relevance of echocardiographically derived EDV and ESV, EF and RFP in HF patients with either ischemic or non ischemic aetiology. Methods. A meta-analysis was performed merging into a single database the individual patient data (demographic, clinical, echo and outcome) of 18 prospective studies investigating the relationship between echocardiographic LV dysfunction and prognosis in HF patients in sinus rhythm. This analysis included 1672 patients with LV volume measurements (mean age 59.6 years, 1331 males); 368 deaths occurred during a median follow-up period of 27.8 months. Results. A RFP (HR 2.11, 95%CI 1.60-2.76, χ 2 p<0.0001), EF (for each unit, HR 0.96, 95%CI 0.94-0.98, χ 2 p<0.0001) and age (for each year, HR 1.04, CI, 1.03-1.06, χ 2 p<0.0001) turned out to be independent predictors of death in ischemic patients. A RFP (HR 3.11, 95%CI 2.07-4.67, χ 2 p<0.0001), ESV (for each ml, HR 1.002, 95%CI 1.001-1.004, χ 2 p=0.0004) and age (for each year, HR 1.03, 95%CI 1.01-1.04, χ 2 p=0.008) were independent predictors of death in non ischemic patients. Conclusions. In HF patients, a restrictive LV filling pattern is the strongest indicator of poor prognosis, irrespective of aetiology. Additional prognostic information is provided either by ESV in non ischemic patients or by EF in ischemic patients en
dc.publisher ELSEVIER SCIENCE BV en
dc.relation.ispartofseries European Journal of Heart Failure en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Cardiac & Cardiovascular Systems en
dc.subject Cardiovascular System & Cardiology en
dc.title Different prognostic relevance of left ventricular volumes and ejection fraction in heart failure patients with ischernic or non ischemic aetiology: A meta analysis en
dc.type Conference Item en
dc.identifier.doi 10.1016/S1567-4215(07)60136-2 en
pubs.issue Suppl en
pubs.begin-page 51 en
pubs.volume 6 en
dc.rights.holder Copyright: ELSEVIER SCIENCE BV en
pubs.author-url http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000247726500139&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d en
pubs.end-page 51 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 328371 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Population Health en
pubs.org-id Epidemiology & Biostatistics en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.record-created-at-source-date 2012-07-30 en

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