Correlation of cellular changes and spatial memory during aging in rats

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Show simple item record Jacobson, Laura en Zhang, Rong en Elliffe, Douglas en Chen, K en Mathai, Sam en McCarthy, Dianne en Waldvogel, Henry en Guan, Jian en 2012-03-21T00:20:45Z en 2012-03-26T23:25:58Z en 2008 en
dc.identifier.citation EXPERIMENTAL GERONTOLOGY 43(10):929-938 01 Oct 2008 en
dc.identifier.issn 0531-5565 en
dc.identifier.uri en
dc.description.abstract We describe neuronal density, neuroplasticity and vascular remodelling and their association with spatial memory in young (4-6 months), middle-aged (9-11 months) and aged (18-20 months) rats of both genders. The neuronal density was reduced in the hippocampus of middle-aged and aged rats, particularly in male rats. However the loss of spatial memory investigated using the Morris water maze, T-maze and 8-radial arm maze tests was found only in the aged groups. The data suggested a pre-symptomatic period of pathological brain aging. Surprisingly, the middle-aged groups showed an elevation of glutamate-decarboxylase immunoreactive neurons in the hippocampus and the striatum, an increase of dopamine output in the striatum and enhanced vascular remodelling in the hippocampus when compared with the young and, in some cases, aged groups. Together, the data suggest that the loss of neurons during midlife may stimulate and enhance neuronal plasticity and vascular remodelling. These compensatory responses to initial neuronal degeneration may play a role in delaying impending memory loss during the pre-symptomatic period of pathological brain aging en
dc.publisher Elsevier en
dc.relation.ispartofseries Experimental Gerontology en
dc.relation.replaces en
dc.relation.replaces 2292/14830 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Correlation of cellular changes and spatial memory during aging in rats en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.exger.2008.08.002 en
pubs.issue 10 en
pubs.begin-page 929 en
pubs.volume 43 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 18761081 en
pubs.end-page 938 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 218859 en Medical and Health Sciences en Medical Sciences en Anatomy and Medical Imaging en Pharmacology en Physiology Division en Science en Science Admin en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18761081 en

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