Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats

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dc.contributor.author Legerlotz, Kirsten en
dc.contributor.author Elliott, Bradley en
dc.contributor.author Guillemin, Bernard en
dc.contributor.author Smith, Heather en
dc.date.accessioned 2012-03-28T23:21:47Z en
dc.date.available 2008-02-11 en
dc.date.issued 2008 en
dc.identifier.citation Experimental Physiology 93(6):754-762 2008 en
dc.identifier.issn 0958-0670 en
dc.identifier.uri http://hdl.handle.net/2292/15876 en
dc.description.abstract The aims of this study were to characterize the pattern of voluntary activity of young rats in response to resistance loading on running wheels and to determine the effects of the activity on the growth of six limb skeletal muscles. Male Sprague–Dawley rats (4 weeks old) were housed individually with a resistance running wheel (R-RUN, n= 7) or a conventional free-spinning running wheel (F-RUN, n= 6) or without a wheel, as non-running control animals (CON, n= 6). The torque required to move the wheel in the R-RUN group was progressively increased, and the activity (velocity, distance and duration of each bout) of the two running wheel groups was recorded continuously for 45 days. The R-RUN group performed many more, shorter and faster bouts of running than the F-RUN group, yet the mean daily distance was not different between the F-RUN (1.3 ± 0.2 km) and R-RUN group (1.4 ± 0.6 km). Only the R-RUN resulted in a significantly (P < 0.05) enhanced muscle wet mass, relative to the increase in body mass, of the plantaris (23%) and vastus lateralis muscle (17%), and the plantaris muscle fibre cross-sectional area, compared with CON. Both F-RUN and R-RUN led to a significantly greater wet mass relative to increase in body mass and muscle fibre cross-sectional area in the soleus muscle compared with CON. We conclude that the pattern of voluntary activity on a resistance running wheel differs from that on a free-spinning running wheel and provides a suitable model to induce physiological muscle hypertrophy in rats. en
dc.language eng en
dc.publisher Wiley en
dc.relation.ispartofseries Experimental Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0958-0670/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Voluntary resistance running wheel activity pattern and skeletal muscle growth in rats en
dc.type Journal Article en
dc.identifier.doi 10.1113/expphysiol.2007.041244 en
pubs.issue 6 en
pubs.begin-page 754 en
pubs.volume 93 en
dc.rights.holder Copyright: The Physiological Society en
dc.identifier.pmid 18281393 en
pubs.author-url http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.2007.041244/abstract en
pubs.end-page 762 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 80830 en
pubs.org-id Engineering en
pubs.org-id Department of Electrical, Computer and Software Engineering en
pubs.org-id Science en
pubs.org-id Exercise Sciences en
dc.identifier.eissn 1469-445X en
pubs.record-created-at-source-date 2012-03-01 en
pubs.dimensions-id 18281393 en

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