dc.contributor.author |
Chand, AL |
en |
dc.contributor.author |
Harrison, CA |
en |
dc.contributor.author |
Shelling, Andrew |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2012-03-28T23:22:55Z |
en |
dc.date.issued |
2010-01 |
en |
dc.identifier.citation |
Human Reproduction Update 16(1):39-50 Jan 2010 |
en |
dc.identifier.issn |
1355-4786 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/15878 |
en |
dc.description.abstract |
Elucidation of the causes of premature ovarian failure (POF) is difficult due to the heterogeneity of the condition. Inhibin is a potential candidate gene for POF based on its dual actions on FSH secretion by the pituitary and gametogenesis in the gonads. A missense mutation in the inhibin alpha subunit gene (INHA G769A) is associated with POF in several populations. However, there is phenotypic heterogeneity in INHA G769A mutation carriers. |
en |
dc.language |
eng |
en |
dc.publisher |
Oxford University Press |
en |
dc.relation.ispartofseries |
Human Reproduction Update |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1355-4786/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Amino Acid Sequence |
en |
dc.subject |
Female |
en |
dc.subject |
Genetic Predisposition to Disease |
en |
dc.subject |
Heterozygote |
en |
dc.subject |
Humans |
en |
dc.subject |
Inhibins |
en |
dc.subject |
Molecular Sequence Data |
en |
dc.subject |
Mutation, Missense |
en |
dc.subject |
Phenotype |
en |
dc.subject |
Primary Ovarian Insufficiency |
en |
dc.subject |
Protein Structure, Tertiary |
en |
dc.subject |
Sequence Alignment |
en |
dc.title |
Inhibin and premature ovarian failure. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1093/humupd/dmp031 |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
39 |
en |
pubs.volume |
16 |
en |
dc.rights.holder |
Copyright: Oxford University Press |
en |
dc.identifier.pmid |
19752047 |
en |
pubs.end-page |
50 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
118409 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1460-2369 |
en |
dc.identifier.pii |
dmp031 |
en |
pubs.record-created-at-source-date |
2012-03-29 |
en |
pubs.dimensions-id |
19752047 |
en |