dc.contributor.author |
Ramachandran, Anassuya |
en |
dc.contributor.author |
Marshall, Elaine |
en |
dc.contributor.author |
Love, Donald |
en |
dc.contributor.author |
Baguley, Bruce |
en |
dc.contributor.author |
Shelling, Andrew |
en |
dc.date.accessioned |
2012-03-28T23:38:13Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Cancer Lett 285(2):157-165 28 Nov 2009 |
en |
dc.identifier.issn |
0304-3835 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/15884 |
en |
dc.description.abstract |
Although activin is a major cytokine produced by the ovary, its role in epithelial ovarian cancer is poorly defined. Here, we demonstrate a novel role for activin as a growth inhibitor of some (8/16) epithelial ovarian cancer cell lines. Unresponsive cell lines displayed transcriptional downregulation of the activin receptors ACTRIIA and ACTRIB, suggesting resistance to activin signalling. In response to activin, growth inhibited cell lines demonstrated activation of the canonical SMAD2/3/4, transcriptional induction of the CDK inhibitor p15INK4B, suppression of C-MYC levels and a G1 phase cell cycle arrest. Thus, activin is a potent inhibitor of proliferation of some epithelial ovarian cancer cell lines and its role in the pathogenesis of this disease needs to be re-evaluated. |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Cancer Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0304-3835/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Activin is a potent growth suppressor of epithelial ovarian cancer cells |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.canlet.2009.05.010 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
157 |
en |
pubs.volume |
285 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
19493612 |
en |
pubs.end-page |
165 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
88950 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19493612 |
en |