dc.contributor.author |
Petermann, Ivonne |
en |
dc.contributor.author |
Triggs, Christopher |
en |
dc.contributor.author |
Huebner, C |
en |
dc.contributor.author |
Han, Dug |
en |
dc.contributor.author |
Gearry, RB |
en |
dc.contributor.author |
Barclay, M |
en |
dc.contributor.author |
Demmers, P |
en |
dc.contributor.author |
McCulloch, A |
en |
dc.contributor.author |
Ferguson, Lynnette |
en |
dc.date.accessioned |
2012-03-30T01:58:38Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
British Journal of Nutrition |
en |
dc.identifier.issn |
0007-1145 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/16167 |
en |
dc.description.abstract |
Carrying a functional single nucleotide polymorphism (L503F, c. 1672 C . T) in the gene for the Na-dependent organic cation transporter (OCTN1), increases the risk of Crohn’s disease (CD) in some, but not all, populations. Case–control data on New Zealand Caucasians show no differences for CD risk between individuals carrying the L503F OCTN1 C-allele when compared with those carrying the variant T-allele. However, more of the New Zealand CD cases report intolerance to maize and mushrooms than those who report beneficial effects or no differences. The OCTN1 gene encodes a transporter for ergothionine, a fungal metabolite at high levels in mushrooms but not widely common in other dietary items. An inability to tolerate mushrooms showed statistically significant associations with the variant OCTN1 genotype. That is, among those individuals reporting adverse effects from mushrooms, there was a higher frequency of the variant T-allele when compared with the general population, or with CD patients overall. We believe that this is a novel gene–diet association, suggesting that individuals carrying the OCTN1 variant single nucleotide polymorphism may have an enhanced risk of adverse symptoms associated with consuming mushrooms. Nutrigenomic approaches to dietary recommendations may be appropriate in this group. |
en |
dc.publisher |
Cambridge University Press |
en |
dc.relation.ispartofseries |
British Journal of Nutrition |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0007-1145/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Mushroom intolerance: a novel diet-gene interaction in Crohn's disease |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1017/S0007114509276446 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
506 |
en |
pubs.volume |
102 |
en |
dc.rights.holder |
Copyright: Cambridge University Press |
en |
dc.identifier.pmid |
19660151 |
en |
pubs.end-page |
508 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
89215 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19660151 |
en |