In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors.

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dc.contributor.author Danesh-Meyer, Helen en
dc.contributor.author Papchenko, T en
dc.contributor.author Savino, PJ en
dc.contributor.author Law, A en
dc.contributor.author Evans, J en
dc.contributor.author Gamble, Gregory en
dc.coverage.spatial United States en
dc.date.accessioned 2012-04-01T20:24:38Z en
dc.date.issued 2008-05 en
dc.identifier.citation Invest Ophthalmol Vis Sci 49(5):1879-1885 May 2008 en
dc.identifier.issn 0146-0404 en
dc.identifier.uri http://hdl.handle.net/2292/16227 en
dc.description.abstract PURPOSE. Restoration of visual function after neurosurgery for parachiasmal tumors is variable and unpredictable. The current study was conducted to determine whether in vivo retinal nerve fiber layer (RNFL) thickness measurements predict the visual recovery of such patients. METHODS. Forty patients undergoing surgical resection of parachiasmal lesions were prospectively assessed before surgery with a neuro-ophthalmic examination, involving standard automated visual field (VF) testing and optical coherence tomography (OCT) measurements of RNFL thickness, which was the prespecified marker for axonal loss. Tests were repeated within 6 weeks after surgery. RESULTS. Thinner preoperative RNFL thickness was associated with worse visual acuity (VA) and VF mean deviation (MD). Patients with normal preoperative RNFL had significant improvement in mean VA after surgery, from 20/40 to 20/25 (P 0.028), whereas patients with thin RNFL did not improve (20/80 to 20/60, P 0.177). Eyes with normal RNFL showed improvement in MD ( 7.0 dB before surgery, 3.5 dB after surgery, P 0.0007) unlike eyes with thin RNFLs, which had no significant improvement after surgery ( 15.3 dB before and 13.3 dB after surgery, P 0.191). RNFL thickness increased by 1% after surgery among all eyes (P 0.04). Eyes with severe VF defects (MD –10 dB) but normal preoperative RNFL thickness showed a postoperative improvement in MD of 14.6 dB compared with 1.6 dB (P 0.0001) in eyes with thin RNFL before surgery, despite no difference in MD before surgery (normal RNFL MD, 22.3 dB; thin RNFL MD, 20.8 dB; P 0.7). CONCLUSIONS. Patients who have objectively measurable RNFL loss at the time of surgery for chiasmal compressive lesions are less likely to have return of VA or VF after surgery. en
dc.language eng en
dc.publisher Association for Research in Vision and Ophthalmology en
dc.relation.ispartofseries Investigative Ophthalmology & Visual Science en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0146-0404/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Adolescent en
dc.subject Adult en
dc.subject Aged en
dc.subject Axons en
dc.subject Decompression, Surgical en
dc.subject Female en
dc.subject Humans en
dc.subject Male en
dc.subject Middle Aged en
dc.subject Ophthalmologic Surgical Procedures en
dc.subject Optic Chiasm en
dc.subject Optic Nerve Neoplasms en
dc.subject Prospective Studies en
dc.subject Recovery of Function en
dc.subject Retinal Ganglion Cells en
dc.subject Tomography, Optical Coherence en
dc.subject Vision Disorders en
dc.subject Visual Acuity en
dc.subject Visual Field Tests en
dc.subject Visual Fields en
dc.title In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. en
dc.type Journal Article en
dc.identifier.doi 10.1167/iovs.07-1127 en
pubs.issue 5 en
pubs.begin-page 1879 en
pubs.volume 49 en
dc.rights.holder Copyright: Association for Research in Vision and Ophthalmology en
dc.identifier.pmid 18263812 en
pubs.end-page 1885 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 185589 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.org-id Ophthalmology Department en
dc.identifier.pii iovs.07-1127 en
pubs.record-created-at-source-date 2012-04-02 en
pubs.dimensions-id 18263812 en


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