dc.contributor.author |
Brittain, Tom |
en |
dc.contributor.author |
Yosaatmadja, Yuliana |
en |
dc.contributor.author |
Henty, Kristen |
en |
dc.date.accessioned |
2012-04-01T21:54:38Z |
en |
dc.date.issued |
2008-02 |
en |
dc.identifier.citation |
IUBMB Life 60(2):135-138 Feb 2008 |
en |
dc.identifier.issn |
1521-6543 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/16280 |
en |
dc.description.abstract |
Neuroglobin has been identified to protect brain neurons from apoptotic stress. Hydrogen sulphide has a role in the brain as a neuromodulator, involving NMDA receptor activation. Here we report on studies of the in vitro interaction of ferric neuroglobin with hydrogen sulphide. Hydrogen sulphide binds very tightly to the heme group of neuroglobin in a biphasic reaction. The faster of the two reaction processes is concentration dependent whilst the slower process is not. The rate of hydrogen sulphide binding is pH sensitive and as the pH is reduced over the physiological range the rate of reaction increases by a factor of similar to 10. This change in reactivity appears to reflect the ionisation of the heme distal His ligand rather than a preference for the binding Of H2S. We discuss the potential role of neuroglobin in the modulation of hydrogen sulphide sensitivity of neurons in the brain. (c) 2008 IUBMB. |
en |
dc.language |
EN |
en |
dc.publisher |
JOHN WILEY & SONS INC |
en |
dc.relation.ispartofseries |
IUBMB Life |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1521-6543/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
neuroglobin |
en |
dc.subject |
hydrogen sulphide |
en |
dc.subject |
binding |
en |
dc.subject |
GLOBIN FAMILY |
en |
dc.subject |
NITRIC-OXIDE |
en |
dc.subject |
CYTOGLOBIN |
en |
dc.subject |
BRAIN |
en |
dc.subject |
H2S |
en |
dc.subject |
NEUROMODULATOR |
en |
dc.subject |
RECEPTOR |
en |
dc.subject |
BINDING |
en |
dc.subject |
OXYGEN |
en |
dc.title |
The interaction of human neuroglobin with hydrogen sulphide |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1002/iub.16 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
135 |
en |
pubs.volume |
60 |
en |
dc.rights.holder |
Copyright: Taylor & Francis Ltd. |
en |
dc.identifier.pmid |
18380003 |
en |
pubs.end-page |
138 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
80122 |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18380003 |
en |