Abstract:
The increase in reactive oxygen species (ROS) production during exercise is well established. However, the specific consequences that an increase in contraction-induced ROS has on cellular function and/or adaptation are not completely understood. An earlier notion that portrayed exercise-induced ROS formation as a necessary evil of muscular contraction, resulting in deleterious effects such as protein or lipid damage, has been transformed over the past several decades into a hormetic effect of exercise-induced ROS signifying that limited exposure to ROS is beneficial whereas a greater, uncontrolled, exposure is harmful.
