Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis

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dc.contributor.author Mittal, A en
dc.contributor.author Hickey, Anthony en
dc.contributor.author Chai, CC en
dc.contributor.author Loveday, BPT en
dc.contributor.author Thompson, NM en
dc.contributor.author Dare, AJ en
dc.contributor.author Delahunt, B en
dc.contributor.author Cooper, Garth en
dc.contributor.author Windsor, John en
dc.contributor.author Phillips, Anthony en
dc.date.accessioned 2012-04-01T23:33:17Z en
dc.date.issued 2011 en
dc.identifier.citation HPB 13(5):332-341 2011 en
dc.identifier.issn 1365-182X en
dc.identifier.uri http://hdl.handle.net/2292/16303 en
dc.description.abstract Introduction:  Multiple organ dysfunction is the main cause of death in severe acute pancreatitis. Primary mitochondrial dysfunction plays a central role in the development and progression of organ failure in critical illness. The present study investigated mitochondrial function in seven tissues during early experimental acute pancreatitis. Methods:  Twenty-eight male Wistar rats (463 ± 2 g; mean ± SEM) were studied. Group 1 (n= 8), saline control; Group 2 (n= 6), caerulein-induced mild acute pancreatitis; Group 3 (n= 7) sham surgical controls; and Group 4 (n= 7), taurocholate-induced severe acute pancreatitis. Animals were euthanased at 6 h from the induction of acute pancreatitis and mitochondrial function was assessed in the heart, lung, liver, kidney, pancreas, duodenum and jejunum by mitochondrial respirometry. Results:  Significant early mitochondrial dysfunction was present in the pancreas, lung and jejunum in both models of acute pancreatitis, however, the Heart, liver, kidney and duodenal mitochondria were unaffected. Conclusions:  The present study provides the first description of early organ-selective mitochondrial dysfunction in the lung and jejunum during acute pancreatitis. Research is now needed to identify the underlying pathophysiology behind the organ selective mitochondrial dysfunction, and the potential benefits of early mitochondrial-specific therapies in acute pancreatitis. en
dc.publisher International Hepato-Pancreato-Biliary Association en
dc.relation.ispartofseries HPB en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1365-182X/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Early organ-specific mitochondrial dysfunction of jejunum and lung found in rats with experimental acute pancreatitis en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1477-2574.2010.00290.x en
pubs.issue 5 en
pubs.begin-page 332 en
pubs.volume 13 en
dc.rights.holder Copyright: International Hepato-Pancreato-Biliary Association en
dc.identifier.pmid 21492333 en
pubs.end-page 341 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 86680 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 21492333 en


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