Malnutritive Obesity (,Malnubesity,): Is It Driven by Human Brain Evolution?

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Show simple item record McGill, Anne-Thea en 2012-04-02T02:11:07Z en 2008 en
dc.identifier.citation Metab Syndr Relat Disord 6(4):241-246 Dec 2008 en
dc.identifier.issn 1540-4196 en
dc.identifier.uri en
dc.description.abstract Health messages on low-energy diets for healthy weight loss are muddled and not working, and obesity rates are rising. Are there missing links? Accumulating evidence shows that humans have well developed ,self-addictive, appetite pathways to enhance the uptake of highly energy-dense food. Humans synthesize fewer cofactors and vitamins than other mammals and must ingest them. Both processes probably arose to maximize available energy for the developing, large association cortex of the human brain. The default phenotype resulting from consuming an ,addictive,, westernized, highly refined, energy-dense, hypomicronutrient diet is ,malnutritive obesity, or ,malnubesity,. A relative lack of antioxidant (and other) co-factors contributes to inefficiently oxidized energy. This ,stress, leads to central fat deposition, disordered energy use by cell mitochondria, especially in muscle and liver, and malfunctioning immune, coagulation, endothelial, and other systems. The resultant problems appear to range from epigenetic reprogramming in utero to end organ damage of the metabolic syndrome and the immune failure of cancer. Treatment of ,malnubesity, may require: (1) understanding the drivers and mechanisms of addictions, (2) reprioritizing satiating, micronutrient-dense whole foods, (3) nonjudgmental general, psychological, and medical support for those at risk or affected by obesity; and (4) practical incentives/regulation for healthy food production and distribution en
dc.publisher Mary Ann Liebert en
dc.relation.ispartofseries Metabolic Syndrome and Related Disorders en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Malnutritive Obesity (,Malnubesity,): Is It Driven by Human Brain Evolution? en
dc.type Journal Article en
dc.identifier.doi 10.1089/met.2008.0031 en
pubs.issue 4 en
pubs.begin-page 241 en
pubs.volume 6 en
dc.rights.holder Copyright: Mary Ann Liebert en
dc.identifier.pmid 19067526 en
pubs.end-page 246 en
pubs.publication-status Published en
dc.rights.accessrights en
pubs.subtype Review en
pubs.elements-id 88041 en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19067526 en

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