dc.contributor.author |
Baker, Charles |
en |
dc.contributor.author |
Vant, MD |
en |
dc.contributor.author |
Dalebout, ML |
en |
dc.contributor.author |
Lento, GM |
en |
dc.contributor.author |
O'Brien, SJ |
en |
dc.contributor.author |
Yuhki, N |
en |
dc.date.accessioned |
2012-04-02T03:16:49Z |
en |
dc.date.issued |
2006-05-01 |
en |
dc.identifier.citation |
IMMUNOGENETICS 58(4):283-296 01 May 2006 |
en |
dc.identifier.issn |
0093-7711 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/16384 |
en |
dc.description.abstract |
The molecular diversity and phylogenetic relationships of two class II genes of the baleen whale major histocompatibility complex were investigated and compared to toothed whales and out-groups. Amplification of the DQB exon 2 provided sequences showing high within-species and between-species nucleotide diversity and uninterrupted reading frames consistent with functional class II loci found in related mammals (e.g., ruminants). Cloning of amplified products indicated gene duplication in the humpback whale and triplication in the southern right whale, with average nucleotide diversity of 5.9 and 6.3%, respectively, for alleles of each species. Significantly higher nonsynonymous divergence at sites coding for peptide binding (32% for humpback and 40% for southern right) suggested that these loci were subject to positive (overdominant) selection. A population survey of humpback whales detected 23 alleles, differing by up to 21% of their inferred amino acid sequences. Amplification of the DRB exon 2 resulted in two groups of sequences. One was most similar to the DRB3 of the cow and present in all whales screened to date, including toothed whales. The second was most similar to the DRB2 of the cow and was found only in the bowhead and right whales. Both loci showed low diversity among species and apparent loss of function or altered function including interruption of reading frames. Finally, comparison of inferred protein sequence of the DRB3-like locus suggested convergence with the DQB, perhaps resulting from intergenic conversion or recombination. |
en |
dc.language |
English |
en |
dc.publisher |
Springer |
en |
dc.relation.ispartofseries |
Immunogenetics |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.
Details obtained from http://www.sherpa.ac.uk/romeo/issn/0093-7711/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Genetics & Heredity |
en |
dc.subject |
Immunology |
en |
dc.subject |
overdominant selection |
en |
dc.subject |
diversity |
en |
dc.subject |
cetaceans |
en |
dc.subject |
dolphins |
en |
dc.subject |
MAJOR HISTOCOMPATIBILITY COMPLEX |
en |
dc.subject |
STRAND CONFORMATION POLYMORPHISM |
en |
dc.subject |
CLASS-I LOCI |
en |
dc.subject |
SEQUENCE VARIATION |
en |
dc.subject |
DELPHINAPTERUS-LEUCAS |
en |
dc.subject |
POPULATION-STRUCTURE |
en |
dc.subject |
NUCLEOTIDE-SEQUENCE |
en |
dc.subject |
HUMPBACK WHALES |
en |
dc.subject |
DNA VARIATION |
en |
dc.subject |
POLYMERASE |
en |
dc.title |
Diversity and duplication of DQB and DRB-like genes of the MHC in baleen whales (suborder : Mysticeti) |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00251-006-0080-y |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
283 |
en |
pubs.volume |
58 |
en |
dc.rights.holder |
Copyright: Springer |
en |
dc.identifier.pmid |
16568262 |
en |
pubs.end-page |
296 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
111833 |
en |
pubs.record-created-at-source-date |
2012-04-02 |
en |
pubs.dimensions-id |
16568262 |
en |