dc.contributor.author |
Young, Robert |
en |
dc.contributor.author |
Hopkins, Raewyn |
en |
dc.contributor.author |
Eaton, TE |
en |
dc.date.accessioned |
2012-04-02T20:08:12Z |
en |
dc.date.issued |
2007-10-01 |
en |
dc.identifier.citation |
European Respiratory Journal 30(4):616-622 01 Oct 2007 |
en |
dc.identifier.issn |
0903-1936 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/16406 |
en |
dc.description.abstract |
The clinical utility of spirometric screening of asymptomatic smokers for early signs of air flow limitation has recently come under review. The current authors propose that reduced forced expiratory volume in one second (FEV1) is more than a measure of airflow limitation, but a marker of premature death with broad utility in assessing baseline risk of chronic obstructive pulmonary disease (COPD), lung cancer, coronary artery disease and stroke, collectively accounting for 70-80% of premature death in smokers.Reduced FEV1 identifies undiagnosed COPD, has comparable utility to that of serum cholesterol in assessing cardiovascular risk and defines those smokers at greatest risk of lung cancer. As such, reduced FEV1 should be considered a marker that identifies smokers at greatest need of medical intervention.Smoking cessation has been shown to attenuate FEV1 decline and, if achieved before the age of 45-50 yrs, may not only preserve FEV1 within normal values but substantially reduce cardiorespiratory complications of smoking.Recent findings suggest inhaled drugs (bronchodilators and corticosteroids), and possibly statins, may be effective in reducing morbidity and mortality in patients with chronic obstructive pulmonary disease. The current authors propose that spirometry has broad utility in identifying smokers who are at greatest risk of cardiorespiratory complications and greatest benefit from targeted preventive strategies, such as smoking cessation, prioritised screening and effective pharmacotherapy. |
en |
dc.language |
English |
en |
dc.publisher |
European Respiratory Society |
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dc.relation.ispartofseries |
European Respiratory Journal |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0903-1936/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Respiratory System |
en |
dc.subject |
baseline risk |
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dc.subject |
chronic obstructive pulmonary disease |
en |
dc.subject |
epidemiology |
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dc.subject |
lung function |
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dc.subject |
premature death |
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dc.subject |
spirometry |
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dc.subject |
OBSTRUCTIVE PULMONARY-DISEASE |
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dc.subject |
NUTRITION EXAMINATION SURVEY |
en |
dc.subject |
CORONARY-HEART-DISEASE |
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dc.subject |
AIR-FLOW OBSTRUCTION |
en |
dc.subject |
1ST NATIONAL-HEALTH |
en |
dc.subject |
SMOKING-CESSATION |
en |
dc.subject |
FOLLOW-UP |
en |
dc.subject |
PRIMARY-CARE |
en |
dc.subject |
INHALED CORTICOSTEROIDS |
en |
dc.subject |
CIGARETTE-SMOKING |
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dc.title |
Forced expiratory volume in one second: not just a lung function test but a marker of premature death from all causes |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1183/09031936.00021707 |
en |
pubs.issue |
4 |
en |
pubs.begin-page |
616 |
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pubs.volume |
30 |
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dc.rights.holder |
Copyright: European Respiratory Society |
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dc.identifier.pmid |
17906084 |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000250135400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.end-page |
622 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
114274 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.record-created-at-source-date |
2012-04-03 |
en |
pubs.dimensions-id |
17906084 |
en |