dc.contributor.author |
Wells, C |
en |
dc.contributor.author |
Salvage-Jones, J |
en |
dc.contributor.author |
Li, X |
en |
dc.contributor.author |
Hitchens, K |
en |
dc.contributor.author |
Butcher, S |
en |
dc.contributor.author |
Murray, R |
en |
dc.contributor.author |
Beckhouse, A |
en |
dc.contributor.author |
Lo, YLS |
en |
dc.contributor.author |
Manzanero, S |
en |
dc.contributor.author |
Cobbold, C |
en |
dc.contributor.author |
Schroder, K |
en |
dc.contributor.author |
Ma, B |
en |
dc.contributor.author |
Orr, S |
en |
dc.contributor.author |
Stewart, L |
en |
dc.contributor.author |
Lebus, D |
en |
dc.contributor.author |
Sobieszczuk, Peter |
en |
dc.contributor.author |
Hume, D |
en |
dc.contributor.author |
Stow, J |
en |
dc.contributor.author |
Blanchard, H |
en |
dc.contributor.author |
Ashman, R |
en |
dc.date.accessioned |
2012-04-02T22:51:27Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Journal of Immunology 180:7404-7413 2008 |
en |
dc.identifier.issn |
0022-1767 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/16482 |
en |
dc.description.abstract |
The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF- by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nonredundant role in the induction of inflammatory signaling in response to C. albicans infection. |
en |
dc.publisher |
American Association of Immunologists |
en |
dc.relation.ispartofseries |
Journal of Immunology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from:
http://www.sherpa.ac.uk/romeo/issn/0022-1767/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans |
en |
dc.type |
Journal Article |
en |
pubs.issue |
10 |
en |
pubs.begin-page |
7404 |
en |
pubs.volume |
180 |
en |
dc.rights.holder |
Copyright: American Association of Immunologists |
en |
pubs.author-url |
http://jimmunol.org/content/180/11/7404.full.pdf+html |
en |
pubs.end-page |
7413 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
333071 |
en |
pubs.record-created-at-source-date |
2012-03-25 |
en |