Synthesis of withanolide A, biological evaluation of its neuritogenic properties, and studies on secretase inhibition

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dc.contributor.author Jana, CK en
dc.contributor.author Hoecker, J en
dc.contributor.author Woods, Tom en
dc.contributor.author Jessen, HJ en
dc.contributor.author Neuburger, M en
dc.contributor.author Gademann, K en
dc.date.accessioned 2012-04-03T21:14:21Z en
dc.date.issued 2011 en
dc.identifier.citation Angewandte Chemie - International Edition 50(36):8407-8411 2011 en
dc.identifier.issn 1433-7851 en
dc.identifier.uri http://hdl.handle.net/2292/16611 en
dc.description.abstract Neurons on steroids: A stereoselective synthesis of the neuritogenic steroid lactone withanolide A was achieved by singlet oxygen ene reaction, Wharton transposition, a Corey–Seebach homologation, and a vinylogous aldol reaction. Biological evaluation demonstrated neurite outgrowth, which supports the potential neuritogenic role of this compound in traditional Indian medicine. en
dc.publisher Wiley - V C H Verlag GmbH & Co. KGaA en
dc.relation.ispartofseries Angewandte Chemie International Edition en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/1433-7851/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Synthesis of withanolide A, biological evaluation of its neuritogenic properties, and studies on secretase inhibition en
dc.type Journal Article en
dc.identifier.doi 10.1002/anie.201101869 en
pubs.issue 36 en
pubs.begin-page 8407 en
pubs.volume 50 en
dc.rights.holder Copyright: Wiley - V C H Verlag GmbH & Co. KGaA en
dc.identifier.pmid 21766402 en
pubs.end-page 8411 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 261152 en
dc.identifier.eissn 1521-3773 en
pubs.record-created-at-source-date 2012-02-02 en
pubs.dimensions-id 21766402 en


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