Controlling of systemic absorption of gliclazide through incorporation into alginate beads

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dc.contributor.author Al-Kassas, Raida en
dc.date.accessioned 2012-04-04T00:28:30Z en
dc.date.issued 2007 en
dc.identifier.citation International Journal of Pharmaceutics 341(102):230-237 2007 en
dc.identifier.issn 0378-5173 en
dc.identifier.uri http://hdl.handle.net/2292/16656 en
dc.description.abstract This work investigates preparation of biodegradable beads with alginate polymer by ionotropic gelation method to take the advantages of the swelling and mucoadhesive properties of alginate beads for improving the oral delivery of the antidiabetic agent gliclazide. It demonstrates that the ionic gelation of alginate molecules offers a flexible and easily controllable process for manipulating the characteristics of the beads which are important in controlling the release rate and consequently the absorption of gliclazide from the gastrointestinal tract. Variations in polymer concentration, stirring speed, internal phase volume and the type of surfactant in the external phase were examined systemically for their effects on the particle size, incorporation efficiency and flow properties of the beads. The swelling behavior was strongly dependent on the polymer concentration in the formulations and the pH of the medium. The in vitro release experiments revealed that the swelling is the main parameter controlling the release rate of gliclazide from the beads. In vivo studies on diabetic rabbits showed that the hypoglycemic effect induced by the gliclazide loaded alginate beads was significantly greater and more prolonged than that induced by the marketed conventional gliclazide tablet (Gliclazide®). The results clearly demonstrated the ability of the system to maintain tight blood glucose level and improved the patient compliance by enhancing, controlling and prolonging the systemic absorption of gliclazide. en
dc.language English en
dc.publisher Elsevier en
dc.relation.ispartofseries International Journal of Pharmaceutics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0378-5173/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Controlling of systemic absorption of gliclazide through incorporation into alginate beads en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.ijpharm.2007.03.047 en
pubs.issue 102 en
pubs.begin-page 230 en
pubs.volume 341 en
dc.rights.holder Copyright: Elsevier en
pubs.end-page 237 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 298366 en
pubs.record-created-at-source-date 2012-02-20 en


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