In vivo and in vitro assessment of the action of the antitumour benzonaphthyridine derivative SN 28049 on the murine Colon 38

Abstract

SN 28049 a new DNA binding benzonaphthyridine derivative targeting the topoisomerase II enzyme is curative against the murine Co38 adenocarcinoma, whereas another agent targeting the same enzyme, etoposide, is relatively ineffective against this tumour.