Characterisation of a transgenic ovine model of Huntington’s disease

Characterisation of a transgenic ovine model of Huntington’s disease

Reid, Susanne ; Handley, R ; Patassini, S ; Rudiger, S ; Keynes, P ; McLaughlan, C ; Waldvogel, H ; Jacobsen, J ; MacDonald, M ; Gusella, J ; Morton, J ; Bawden, S ; Faull, R ; Snell, R

Identifier: http://hdl.handle.net/2292/17188

Issue Date: 2011-09-11

Reference: World Congress on Huntington's Disease. 11 Sep 2011

Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

A transgenic ovine model of Huntington’s disease has been developed to enable the examination of the earliest disease changes in a large mammal. Ovis aries were selected because their basal ganglia and cortex is similar to analogous regions of the human brain. Importantly, they live for more than a decade, allowing for the study of the chronic effects of a fulllength HTT expressing transgene. Microinjection of a fulllength human HD cDNA containing 73 polyglutamine repeats under the control of the human promoter, resulted in six transgenic founders varying in copy-number of the transgene.

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