dc.contributor.author |
Reid, Susanne |
en |
dc.contributor.author |
Handley, R |
en |
dc.contributor.author |
Patassini, S |
en |
dc.contributor.author |
Rudiger, S |
en |
dc.contributor.author |
Keynes, P |
en |
dc.contributor.author |
McLaughlan, C |
en |
dc.contributor.author |
Waldvogel, H |
en |
dc.contributor.author |
Jacobsen, J |
en |
dc.contributor.author |
MacDonald, M |
en |
dc.contributor.author |
Gusella, J |
en |
dc.contributor.author |
Morton, J |
en |
dc.contributor.author |
Bawden, S |
en |
dc.contributor.author |
Faull, R |
en |
dc.contributor.author |
Snell, R |
en |
dc.coverage.spatial |
Melbourne, Australia |
en |
dc.date.accessioned |
2012-04-15T21:34:03Z |
en |
dc.date.issued |
2011-09-11 |
en |
dc.identifier.citation |
World Congress on Huntington's Disease. 11 Sep 2011 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/17188 |
en |
dc.description.abstract |
A transgenic ovine model of Huntington’s disease has been developed to enable the examination of the earliest disease changes in a large mammal. Ovis aries were selected because their basal ganglia and cortex is similar to analogous regions of the human brain. Importantly, they live for more than a decade, allowing for the study of the chronic effects of a fulllength HTT expressing transgene. Microinjection of a fulllength human HD cDNA containing 73 polyglutamine repeats under the control of the human promoter, resulted in six transgenic founders varying in copy-number of the transgene. |
en |
dc.description.uri |
http://www.worldcongress-hd2011.org/ |
en |
dc.relation.ispartof |
World Congress on Huntington's Disease |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Characterisation of a transgenic ovine model of Huntington’s disease |
en |
dc.type |
Conference Poster |
en |
dc.identifier.doi |
10.1111/j.1399-0004.2011.01737.x |
en |
pubs.begin-page |
27 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
257650 |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.record-created-at-source-date |
2011-12-08 |
en |