Characterisation of a transgenic ovine model of Huntington’s disease

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Show simple item record Reid, Susanne en Handley, R en Patassini, S en Rudiger, S en Keynes, P en McLaughlan, C en Waldvogel, H en Jacobsen, J en MacDonald, M en Gusella, J en Morton, J en Bawden, S en Faull, R en Snell, R en
dc.coverage.spatial Melbourne, Australia en 2012-04-15T21:34:03Z en 2011-09-11 en
dc.identifier.citation World Congress on Huntington's Disease. 11 Sep 2011 en
dc.identifier.uri en
dc.description.abstract A transgenic ovine model of Huntington’s disease has been developed to enable the examination of the earliest disease changes in a large mammal. Ovis aries were selected because their basal ganglia and cortex is similar to analogous regions of the human brain. Importantly, they live for more than a decade, allowing for the study of the chronic effects of a fulllength HTT expressing transgene. Microinjection of a fulllength human HD cDNA containing 73 polyglutamine repeats under the control of the human promoter, resulted in six transgenic founders varying in copy-number of the transgene. en
dc.description.uri en
dc.relation.ispartof World Congress on Huntington's Disease en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Characterisation of a transgenic ovine model of Huntington’s disease en
dc.type Conference Poster en
dc.identifier.doi 10.1111/j.1399-0004.2011.01737.x en
pubs.begin-page 27 en
dc.rights.accessrights en
pubs.elements-id 257650 en Science en Biological Sciences en
pubs.record-created-at-source-date 2011-12-08 en

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