Islet human amylin oligomer formation is differentially correlated with β-cell death and diabetes onset between homozygous and hemizygous human amylin transgenic mice

Zhang, S; Liu, H; Li, XL; Au, M; Chuang, CL; Cooper, GJS

dc.contributor.author	Zhang, S	en
dc.contributor.author	Liu, H	en
dc.contributor.author	Li, XL	en
dc.contributor.author	Au, M	en
dc.contributor.author	Chuang, CL	en
dc.contributor.author	Cooper, GJS	en
dc.coverage.spatial	Stockholm, Sweden	en
dc.date.accessioned	2012-04-15T21:48:28Z	en
dc.date.available	2012-04-15T21:48:28Z	en
dc.date.issued	2010	en
dc.identifier.citation	The 46th Annual Meeting of European Association for the Study of Diabetes (EASD). 20 Sep 2010	en
dc.identifier.uri	http://hdl.handle.net/2292/17192	en
dc.description.abstract	One of the pathological features of type-2 diabetes mellitus (T2DM) is the presence of islet amyloid deposits comprising mainly human amylin (hA)/hIAPP. Recent studies suggested that soluble oligomers of human amylin may be the primary cause of β-cell damage and thus contribute to the onset/development of T2DM. However, the molecular basis of this process remains to be fully elucidated. We aimed to investigate the connection between soluble oligomers and hA cytotoxicity, and their correlation with diabetes development using a rodent model of diabetes.	en
dc.relation.ispartof	The 46th Annual Meeting of European Association for the Study of Diabetes (EASD)	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.source.uri	http://www.easd.org/	en
dc.title	Islet human amylin oligomer formation is differentially correlated with β-cell death and diabetes onset between homozygous and hemizygous human amylin transgenic mice	en
dc.type	Conference Poster	en
pubs.author-url	http://www.easd.org/	en
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dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.elements-id	194789	en
pubs.org-id	Faculty of Science	en
pubs.org-id	Biological Sciences	en
pubs.org-id	Science Resrch Insts & Centres	en
pubs.org-id	Maurice Wilkins Centre	en