dc.contributor.author |
Grey, Angus |
en |
dc.contributor.author |
Crouch, RK |
en |
dc.contributor.author |
Koutalos, Y |
en |
dc.contributor.author |
Schey, KL |
en |
dc.contributor.author |
Ablonczy, Z |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2012-04-27T02:31:13Z |
en |
dc.date.issued |
2011-06 |
en |
dc.identifier.citation |
Investigative Ophthalmology & Visual Science 52(7):3926-3933 Jun 2011 |
en |
dc.identifier.issn |
0146-0404 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/17587 |
en |
dc.description.abstract |
Lipofuscin, a fluorescent lysosomal pigment made of lipophilic molecules, is associated with age-related pathophysiological processes in the retinal pigment epithelium (RPE). The best-characterized components of lipofuscin are A2E and its oxides, but a direct spatial correlation with lipofuscin has not previously been possible. |
en |
dc.language |
eng |
en |
dc.publisher |
The Association for Research in Vision and Ophthalmology, Inc. |
en |
dc.relation.ispartofseries |
Investigative Ophthalmology & Visual Science |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0146-0404/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
ATP-Binding Cassette Transporters |
en |
dc.subject |
Animals |
en |
dc.subject |
Female |
en |
dc.subject |
Lipofuscin |
en |
dc.subject |
Macular Degeneration |
en |
dc.subject |
Male |
en |
dc.subject |
Mice |
en |
dc.subject |
Mice, 129 Strain |
en |
dc.subject |
Mice, Mutant Strains |
en |
dc.subject |
Microscopy, Fluorescence |
en |
dc.subject |
Oxidation-Reduction |
en |
dc.subject |
Oxides |
en |
dc.subject |
Pyridinium Compounds |
en |
dc.subject |
Retinal Pigment Epithelium |
en |
dc.subject |
Retinoids |
en |
dc.subject |
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
en |
dc.title |
Spatial localization of A2E in the retinal pigment epithelium. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1167/iovs.10-7020 |
en |
pubs.issue |
7 |
en |
pubs.begin-page |
3926 |
en |
pubs.volume |
52 |
en |
dc.rights.holder |
Copyright: The Association for Research in Vision and Ophthalmology, Inc. |
en |
dc.identifier.pmid |
21357388 |
en |
pubs.end-page |
3933 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
206837 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
dc.identifier.pii |
iovs.10-7020 |
en |
pubs.record-created-at-source-date |
2012-04-27 |
en |
pubs.dimensions-id |
21357388 |
en |