Bioorganometallic chemistry-from teaching paradigms to medicinal applications

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dc.contributor.author Hartinger, Christian en
dc.contributor.author Dyson, Paul J en
dc.date.accessioned 2012-04-29T21:14:25Z en
dc.date.issued 2009 en
dc.identifier.citation Chemical Society Reviews 38(2):391-401 2009 en
dc.identifier.issn 0306-0012 en
dc.identifier.uri http://hdl.handle.net/2292/17600 en
dc.description.abstract In undergraduate level organometallic chemistry courses students are usually taught that organometallic compounds are toxic and unstable in air and water. While this is true of many complexes, some are also non-toxic and stable in air and water. Indeed, bioorganometallic chemistry, the study of biomolecules or biologically active molecules that contain at least one carbon directly bound to a metal, is a thriving subject, and air and water stability is a general pre-requisite. This interdisciplinary field is located at the borderline between chemistry, biochemistry, biology and medicine. In this tutorial review, various aspects of bioorganometallic chemistry are introduced, with the main emphasis on medicinal organometallic compounds. Organometallic therapeutics for cancer, HIV and malaria and other medicinal applications are described. It is also shown how rational ligand design has led to new improved therapies much in the same way that an organometallic chemist working in catalysis will design new ligands for improved activities. en
dc.language English en
dc.publisher The Royal Society of Chemistry en
dc.relation.ispartofseries Chemical Society Reviews en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0306-0012/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Science & Technology en
dc.subject Physical Sciences en
dc.subject Chemistry, Multidisciplinary en
dc.subject Chemistry en
dc.subject HALF-SANDWICH COMPLEXES en
dc.subject ANTICANCER DRUGS en
dc.subject ANTITUMOR-ACTIVITY en
dc.subject ORGANOMETALLIC CHEMISTRY en
dc.subject TITANOCENE DICHLORIDE en
dc.subject RUTHENIUM COMPLEXES en
dc.subject ELECTRON-TRANSFER en
dc.subject BREAST-CANCER en
dc.subject CELL LINES en
dc.subject PROTEIN en
dc.title Bioorganometallic chemistry-from teaching paradigms to medicinal applications en
dc.type Journal Article en
dc.identifier.doi 10.1039/b707077m en
pubs.issue 2 en
pubs.begin-page 391 en
pubs.volume 38 en
dc.rights.holder Copyright: The Royal Society of Chemistry en
dc.identifier.pmid 19169456 en
pubs.author-url http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000264374600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d en
pubs.end-page 401 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 238808 en
pubs.org-id Science en
pubs.org-id Chemistry en
pubs.record-created-at-source-date 2012-04-30 en
pubs.dimensions-id 19169456 en


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