Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide.

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dc.contributor.author Gorman, Desmond en
dc.contributor.author Huang, YL en
dc.coverage.spatial Ireland en
dc.date.accessioned 2012-05-13T21:35:20Z en
dc.date.issued 2008-10-24 en
dc.identifier.citation Neurosci Lett 444(2):203-207 24 Oct 2008 en
dc.identifier.issn 0304-3940 en
dc.identifier.uri http://hdl.handle.net/2292/17935 en
dc.description.abstract Carbon monoxide (CO) usually does not damage the brain cortex in our in vivo model. To investigate the possible protective role of responsive and regulated changes in blood flow, 24 ewes were randomly assigned in equal numbers to sham-control, CO-control and treatment (haeme oxygenase (HO) and nitric oxide synthetase (NOS) inhibited) groups. Sheep in the second and third groups were then anaesthetised with CO for 2 h. Brain blood flow was measured using Laser Doppler and was increased in CO exposed sheep. The CO-induced anaesthesia was associated with isolated brain white matter damage. In the HO/NOS inhibited sheep, cortical EEG recovery after the anaesthesia was slower and incomplete, and cortical blood flow increased whereas white matter flow decreased. These results confirm our earlier findings that the induction of HO and NOS by CO inhalation is protective, but, suggest a relationship between tissue injury and blood flow that is perhaps partly causal. en
dc.language eng en
dc.publisher Elsevier en
dc.relation.ispartofseries Neuroscience Letters en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0304-3940/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Brain en
dc.subject Carbon Monoxide en
dc.subject Cerebrovascular Circulation en
dc.subject Electroencephalography en
dc.subject Female en
dc.subject Heme Oxygenase (Decyclizing) en
dc.subject Nitric Oxide Synthase en
dc.subject Random Allocation en
dc.subject Sheep en
dc.title Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.neulet.2008.08.038 en
pubs.issue 2 en
pubs.begin-page 203 en
pubs.volume 444 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 18723078 en
pubs.end-page 207 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 143225 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
dc.identifier.pii S0304-3940(08)01091-4 en
pubs.record-created-at-source-date 2012-05-14 en
pubs.dimensions-id 18723078 en

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