dc.contributor.author |
Gorman, Desmond |
en |
dc.contributor.author |
Huang, YL |
en |
dc.coverage.spatial |
Ireland |
en |
dc.date.accessioned |
2012-05-13T21:35:20Z |
en |
dc.date.issued |
2008-10-24 |
en |
dc.identifier.citation |
Neurosci Lett 444(2):203-207 24 Oct 2008 |
en |
dc.identifier.issn |
0304-3940 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/17935 |
en |
dc.description.abstract |
Carbon monoxide (CO) usually does not damage the brain cortex in our in vivo model. To investigate the possible protective role of responsive and regulated changes in blood flow, 24 ewes were randomly assigned in equal numbers to sham-control, CO-control and treatment (haeme oxygenase (HO) and nitric oxide synthetase (NOS) inhibited) groups. Sheep in the second and third groups were then anaesthetised with CO for 2 h. Brain blood flow was measured using Laser Doppler and was increased in CO exposed sheep. The CO-induced anaesthesia was associated with isolated brain white matter damage. In the HO/NOS inhibited sheep, cortical EEG recovery after the anaesthesia was slower and incomplete, and cortical blood flow increased whereas white matter flow decreased. These results confirm our earlier findings that the induction of HO and NOS by CO inhalation is protective, but, suggest a relationship between tissue injury and blood flow that is perhaps partly causal. |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Neuroscience Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0304-3940/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Animals |
en |
dc.subject |
Brain |
en |
dc.subject |
Carbon Monoxide |
en |
dc.subject |
Cerebrovascular Circulation |
en |
dc.subject |
Electroencephalography |
en |
dc.subject |
Female |
en |
dc.subject |
Heme Oxygenase (Decyclizing) |
en |
dc.subject |
Nitric Oxide Synthase |
en |
dc.subject |
Random Allocation |
en |
dc.subject |
Sheep |
en |
dc.title |
Haeme oxygenase and nitric oxide synthetase blockade and brain blood flow in sheep exposed to carbon monoxide. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.neulet.2008.08.038 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
203 |
en |
pubs.volume |
444 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
18723078 |
en |
pubs.end-page |
207 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
143225 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
dc.identifier.pii |
S0304-3940(08)01091-4 |
en |
pubs.record-created-at-source-date |
2012-05-14 |
en |
pubs.dimensions-id |
18723078 |
en |