dc.contributor.advisor |
Reichert, WM |
en |
dc.contributor.advisor |
Klitzman, B |
en |
dc.contributor.author |
Koschwanez, Heidi |
en |
dc.date.accessioned |
2012-05-13T21:38:39Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Sub type: PhD Thesis. Supervisors: Reichert WM, Klitzman B. Duke University, 2009 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/17936 |
en |
dc.description.abstract |
Efforts to create a reliable, long–term implantable glucose sensor have been stymied by the effects of the foreign body response and wound healing that introduce delayed response times as well as unpredictable sensor performance. Loss of vascularization from fibrotic encapsulation around implanted sensors is purported as a key contributor to sensor failure, as glucose and oxygen transport to the sensor becomes impeded. Improving sensor performance by increasing angiogenesis and/or reducing capsule thickness using tissue-modifying textured coatings is attractive because texturing is not dependent upon a depletable drug reservoir. A significant range of materials and pore sizes are capable of promoting angiogenesis and reducing capsule thickness, provided pores have open-architecture with dimensions sufficiently large enough to allow inflammatory cell infiltration. |
en |
dc.publisher |
Duke University |
en |
dc.relation.ispartof |
PhD Thesis - University of Auckland |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
The effects of porous poly-L-lactic acid coatings on tissue response and subsequent glucose sensor performance |
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dc.type |
Thesis |
en |
thesis.degree.grantor |
Duke University |
en |
thesis.degree.level |
Doctoral |
en |
thesis.degree.name |
PhD |
en |
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
http://dukespace.lib.duke.edu/dspace/handle/10161/1206 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
345458 |
en |
pubs.record-created-at-source-date |
2012-05-04 |
en |