dc.contributor.author |
Gorman, Desmond |
en |
dc.contributor.author |
Lin, HY |
en |
dc.contributor.author |
Williams, Christopher |
en |
dc.date.accessioned |
2012-05-13T21:39:06Z |
en |
dc.date.issued |
2006 |
en |
dc.identifier.citation |
Neurosci Lett 394(3):174-178 20 Feb 2006 |
en |
dc.identifier.issn |
0304-3940 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/17937 |
en |
dc.description.abstract |
Hypoxaemia consequent to inspired carbon monoxide (CO), and to other causes, often does not injure the brain cortex. At least five types of brain and heart protective cardiovascular response to hypoxaemia have been reported. The underlying mechanism is unknown. The present study was designed to test the hypothesis that the reaction to inspired CO involves the amygdala as this structure is thought to be central to stress responsivity; involvement would support the additional hypothesis that the somatic response to CO-hypoxaemia is regulated. Eighteen ewes were randomly allocated to control and two CO groups. The CO groups were exposed to 1% CO for 120 min and killed either 5 or 15 days later. This exposure caused isolated white matter brain injury and a transient increase in protein-kinase C (gamma) activity in the pyramidal neurons in the nuclei of the central and basal–lateral amygdala and in the neurons of the audio-cortex (p < 0.05). This was associated with evidence of a sympathetic response. It would seem reasonable to hypothesise both that the amygdala is important in the processes by which the hypoxaemic effects of CO on the brain are prevented, delayed and/or mitigated and that these processes are regulated. |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Neuroscience Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0304-3940/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Early evidence of a regulated response to hypoxaemia in sheep that preserves the brain cortex. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.neulet.2005.10.075 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
174 |
en |
pubs.volume |
394 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
16300896 |
en |
pubs.end-page |
178 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
69894 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
16300896 |
en |