Size at birth and adult fat mass in twin sheep are determined in early gestation

Show simple item record Hancock, SN en Oliver, Mark en McLean, C en Jaquiery, Anne en Bloomfield, Francis en
dc.coverage.spatial England en 2012-03-18T20:44:33Z en 2012-05-22T20:19:04Z en 2012-02 en
dc.identifier.citation J Physiol 590(Pt 5):1273-1285 01 Mar 2012 en
dc.identifier.issn 0022-3751 en
dc.identifier.uri en
dc.description.abstract Key points   Reduced size at birth and shorter gestation length are both associated with increased risks of non-communicable diseases (NCD) in later adult life.  Twins are born both smaller and earlier than singletons and adult twins also are reported to be at increased risk of common NCDs such as diabetes.  The smaller size and shorter gestation length of twins has been presumed to be due to a lack of intrauterine space and/or limitations of placental nutrient supply in late gestation, but there are few data to support this.  We show that size at birth and adult fat mass in twin sheep are determined largely in early gestation.  Knowledge of the mechanisms underlying early pregnancy determination of fetal growth and gestation length in twins are likely to increase understanding of how early pregnancy factors influence lifelong health for offspring from all pregnancies. en
dc.language eng en
dc.publisher The Physiological Society; The Authors en
dc.relation.ispartofseries Journal of Physiology en
dc.relation.replaces en
dc.relation.replaces 2292/14600 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title Size at birth and adult fat mass in twin sheep are determined in early gestation en
dc.type Journal Article en
dc.identifier.doi 10.1113/jphysiol.2011.220699 en
pubs.issue Pt 5 en
pubs.begin-page 1273 en
pubs.volume 590 en
dc.rights.holder Copyright: The Physiological Society; The Authors en
dc.identifier.pmid 22183720 en en
pubs.end-page 1285 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 340893 en Liggins Institute en LiFePATH en
dc.identifier.eissn 1469-7793 en
dc.identifier.pii jphysiol.2011.220699 en
pubs.record-created-at-source-date 2012-03-19 en
pubs.dimensions-id 22183720 en

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