Adrenocorticotropic hormone analogs and related methods

Brennan, MB; Costa, Jessica; Dores, RM; Hochgeschwender, U; Haskell-Luevano, C

dc.contributor.author	Brennan, MB	en
dc.contributor.author	Costa, Jessica	en
dc.contributor.author	Dores, RM	en
dc.contributor.author	Hochgeschwender, U	en
dc.contributor.author	Haskell-Luevano, C	en
dc.coverage.spatial	United States	en
dc.date.accessioned	2012-05-22T22:17:51Z	en
dc.date.issued	2007	en
dc.date.submitted	2005-10-27	en
dc.identifier.citation	Patent/Trademark number: US 7,264,314 B2 (USA). Application number: 11/260,551. Awarded date: 04 Sep 2007	en
dc.identifier.govdoc	US 7264314	en
dc.identifier.uri	http://hdl.handle.net/2292/18116	en
dc.description.abstract	ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.	en
dc.description.uri	http://www.uspto.gov/	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Adrenocorticotropic hormone analogs and related methods	en
dc.type	Patent	en
dc.rights.holder	Copyright: The Authors	en
pubs.author-url	http://www.patentlens.net/patentlens/patents.html?patnums=US_7264314&language=en&	en
pubs.patent-status	Granted	en
pubs.start-date	2007	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.elements-id	49789	en
pubs.number	11/260,551	en
pubs.record-created-at-source-date	2010-09-01	en