In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors

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dc.contributor.author Koschwanez, Heidi en
dc.contributor.author Yap, FY en
dc.contributor.author Klitzman, B en
dc.contributor.author Reichert, WM en
dc.date.accessioned 2012-05-22T22:20:59Z en
dc.date.issued 2008 en
dc.identifier.citation Journal of Biomedical Materials Research - Part A 87(3):792-807 2008 en
dc.identifier.issn 1549-3296 en
dc.identifier.uri http://hdl.handle.net/2292/18117 en
dc.description.abstract The purpose of this study was to test the hypothesis that porous poly-L-lactic acid (PLLA) sensor coatings reduce fibrosis and promote blood microvessel formation in tissue adjacent to the sensor surface. Porous PLLA coatings were produced using ammonium bicarbonate as the gas foaming/salt leaching agent, and deployed on functional and nonfunctional sensors. The porous coatings minimally affected sensor accuracy and response rate in vitro. Three-week subcutaneous rat studies of nonfunctional glucose sensors showed the anticipated effect of porous coatings enhancing vascularity and decreasing collagen deposition. In contrast, percutaneous functional sensors with and without porous coatings showed no significant difference in terms of histology or sensor response. In spite of the observation that texturing increases the vascularity of the tissue that surrounds implanted sensors, other factors such as the additional mechanical stresses imposed by percutaneous tethering may override the beneficial effects of the porous coatings. en
dc.publisher Australasian Society for Biomaterials; Japanese Society for Biomaterials ; Korean Society for Biomaterials ; Society For Biomaterials (USA); Wiley Periodicals en
dc.relation.ispartofseries Journal of Biomedical Materials Research - Part A en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1549-3296/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title In vitro and in vivo characterization of porous poly-L-lactic acid coatings for subcutaneously implanted glucose sensors en
dc.type Journal Article en
dc.identifier.doi 10.1002/jbm.a.31824 en
pubs.issue 3 en
pubs.begin-page 792 en
pubs.volume 87 en
dc.rights.holder Copyright: Australasian Society for Biomaterials; Japanese Society for Biomaterials ; Korean Society for Biomaterials ; Society For Biomaterials (USA); Wiley Periodicals en
dc.identifier.pmid 18200540 en
pubs.end-page 807 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 225901 en
dc.identifier.eissn 1552-4965 en
pubs.record-created-at-source-date 2012-05-23 en
pubs.dimensions-id 18200540 en


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