dc.contributor.author |
Fraser, John |
en |
dc.contributor.author |
Proft, Thomas |
en |
dc.date.accessioned |
2012-05-23T00:35:51Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Immunol Rev 225:226-243 Oct 2008 |
en |
dc.identifier.issn |
0105-2896 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18161 |
en |
dc.description.abstract |
The bacterial superantigens are protein toxins that bind to major histocompatibility complex class II and T-cell receptor to stimulate large numbers of T cells. The majority are produced by the Gram-positive organisms Staphylococcus aureus and Streptococcus pyogenes and are the causative agents in toxic shock syndrome, an acute disease caused by the sudden and massive release of T-cell cytokines into the blood stream. The structure and function of the superantigens has revealed a common architecture that is also shared by another group of staphylococcal virulence factors called the superantigen-like proteins (SSL). Together, this family of structurally related molecules highlights how a common pathogenic organism has employed a simple but adaptable protein to generate an armamentarium of potent defense molecules designed to target of the innate and adaptive immune response. |
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dc.description.uri |
http://dx.doi.org/10.1111/j.1600-065X.2008.00681.x |
en |
dc.publisher |
John Wiley and Sons |
en |
dc.relation.ispartofseries |
Immunological Reviews |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0105-2896/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
The bacterial superantigen and superantigen-like proteins |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1111/j.1600-065X.2008.00681.x |
en |
pubs.issue |
1 |
en |
pubs.begin-page |
226 |
en |
pubs.volume |
225 |
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dc.rights.holder |
Copyright: John Wiley and Sons |
en |
dc.identifier.pmid |
18837785 |
en |
pubs.end-page |
243 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Review |
en |
pubs.elements-id |
85049 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
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pubs.dimensions-id |
18837785 |
en |