The impact of early nutrition in premature infants on later childhood insulin sensitivity and growth

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Show simple item record Reagan, F en Cutfield, Wayne en Jefferies, Craig en Robinson, Elizabeth en Hofman, Paul en 2012-05-23T21:02:30Z en 2006 en
dc.identifier.citation Pediatrics 118(5):1943-1949 Nov 2006 en
dc.identifier.issn 0031-4005 en
dc.identifier.uri en
dc.description.abstract OBJECTIVES. Children born prematurely have decreased insulin sensitivity. The etiology of this insulin resistance is unknown. The aim of this study was to evaluate infant nutrition and its influence on insulin sensitivity and postnatal growth in children born ≤32 weeks’ gestation. METHODS. A total of 56 healthy, developmentally normal, prepubertal children, aged 4 to 10 years were recruited. Thirty-seven were born ≤32 weeks’ gestation, and 19 were control subjects born at term with a birth weight >10th percentile. Insulin sensitivity (10−4 min−1 μU/mL) was calculated from a 90-minute frequently sampled intravenous glucose tolerance test. Perinatal, nutritional, and growth data were obtained retrospectively from both neonatal and early infancy records in the premature cohort. RESULTS. Children born prematurely had decreased insulin sensitivity when compared with those born at term (13.8 vs 30.6). Neonatal nutrition was not correlated with insulin sensitivity; however, all of the infants had inadequate protein in the first month followed by excessive fat intake thereafter. Premature children with greater weight gain had lower insulin sensitivity. Higher carbohydrate intake in the first month of life was associated with greater weight gain from birth. No relationship was seen between weight gain and either protein or lipid intake. CONCLUSIONS. Prematurely born children are insulin resistant and have suboptimal neonatal nutrition. Greater childhood weight gain magnifies this reduction in insulin sensitivity and seems to be associated with early nutrition. We speculate that a high carbohydrate neonatal diet may lead to greater weight gain and a greater reduction in insulin sensitivity in this group. en
dc.publisher American Academy of Pediatrics en
dc.relation.ispartofseries Paediatrics en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.title The impact of early nutrition in premature infants on later childhood insulin sensitivity and growth en
dc.type Journal Article en
dc.identifier.doi 10.1542/peds.2006-0733 en
pubs.issue 5 en
pubs.begin-page 1943 en
pubs.volume 118 en
dc.rights.holder Copyright: American Academy of Pediatrics en
dc.identifier.pmid 17079565 en
pubs.end-page 1949 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 70740 en Liggins Institute en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 17079565 en

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