The serine protease inhibitor neuroserpin regulates the growth and maturation of hippocampal neurons through a non-inhibitory mechanism

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dc.contributor.author Lee, Tet en
dc.contributor.author Montgomery, JM en
dc.contributor.author Birch, Nigel en
dc.date.accessioned 2012-05-24T23:37:32Z en
dc.date.issued 2012-05 en
dc.identifier.citation Journal of Neurochemistry 121(4):561-574 May 2012 [Available online 2011] en
dc.identifier.issn 0022-3042 en
dc.identifier.uri http://hdl.handle.net/2292/18410 en
dc.description.abstract Neuroserpin is a brain-specific serine protease inhibitor that is expressed in the developing and adult nervous system. Its expression profile led to suggestions that it played roles in neuronal growth and connectivity. In this study, we provide direct evidence to support a role for neuroserpin in axon and dendritic growth. We report that axon growth is enhanced while axon and dendrite diameter are reduced following neuroserpin treatment of hippocampal neurons. More complex effects are seen on dendritic growth and branching with neuroserpin-stimulating dendritic growth and branching in young neurons but switching to an inhibitory response in older neurons. The protease inhibitory activity of neuroserpin is not required to activate changes in neuronal morphology and a proportion of responses are modulated by an antagonist to the LRP1 receptor. Collectively, these findings support a key role for neuroserpin as a regulator of neuronal development through a non-inhibitory mechanism and suggest a basis for neuroserpin's effects on complex emotional behaviours and recent link to schizophrenia. en
dc.publisher Wiley-Blackwell; International Society for Neurochemistry en
dc.relation.ispartofseries Journal of Neurochemistry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0022-3042/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title The serine protease inhibitor neuroserpin regulates the growth and maturation of hippocampal neurons through a non-inhibitory mechanism en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1471-4159.2011.07639.x en
pubs.issue 4 en
pubs.begin-page 561 en
pubs.volume 121 en
dc.rights.holder Copyright: Wiley-Blackwell; International Society for Neurochemistry en
pubs.end-page 574 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 258806 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.record-created-at-source-date 2011-12-11 en


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