dc.contributor.author |
Tham, LS |
en |
dc.contributor.author |
Wang, L |
en |
dc.contributor.author |
Soo, RA |
en |
dc.contributor.author |
Lee, SC |
en |
dc.contributor.author |
Lee, HS |
en |
dc.contributor.author |
Yong, WP |
en |
dc.contributor.author |
Goh, BC |
en |
dc.contributor.author |
Holford, Nicholas |
en |
dc.date.accessioned |
2012-05-24T23:54:22Z |
en |
dc.date.issued |
2008-07-01 |
en |
dc.identifier.citation |
CLINICAL CANCER RESEARCH 14(13):4213-4218 01 Jul 2008 |
en |
dc.identifier.issn |
1078-0432 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18416 |
en |
dc.description.abstract |
Purpose: This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabine or that of its metabolites, 2',2'-difluorodeoxyuridine or gemcitabine triphosphate, are better than gemcitabine dose for prediction of individual response.Experimental Design: Gemcitabine was given thrice weekly on days 1 and 8 in combination with carboplatin, which was given only on day 1 of every cycle. Gemcitabine amount in the body and area under the concentration-time curves of plasma gemcitabine, 2',2'-difluorodeoxyuridine, and intracellular gemcitabine triphosphate in white cells were compared to determine which best describes tumor shrinkage over time. Tumor growth kinetics were described using a Gompertz-like model.Results: The apparent half-life for the effect of gemcitabine was 7.67 weeks. The tumor turnover time constant was 21.8 week-cm. Baseline tumor size and gemcitabine amount in the body to attain 50% of tumor shrinkage were estimated to be 6.66 cm and 10,600 mg. There was no evidence of relapse during treatment.Conclusions: C oncentrati on-based exposure metrics for gemcitabine and its metabolites were no better than gemcitabine amount in predicting tumor shrinkage in primary lung cancer lesions. Gemcitabine dose-based models did marginally better than treatment-based models that ignored doses of drug administered to patients. Modeling tumor shrinkage in primary lesions can be used to quantify individual sensitivity and response to antitumor effects of anticancer drugs. |
en |
dc.language |
English |
en |
dc.publisher |
American Association for Cancer Research |
en |
dc.relation.ispartofseries |
Clinical Cancer Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1078-0432/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Oncology |
en |
dc.subject |
RANDOMIZED PHASE-II |
en |
dc.subject |
DOSE RATE INFUSION |
en |
dc.subject |
SOLID TUMORS |
en |
dc.subject |
GOMPERTZIAN GROWTH |
en |
dc.subject |
TRIAL |
en |
dc.subject |
2',2'-DIFLUORODEOXYCYTIDINE |
en |
dc.subject |
MYELOSUPPRESSION |
en |
dc.subject |
PHARMACOLOGY |
en |
dc.subject |
CARCINOMA |
en |
dc.subject |
DYNAMICS |
en |
dc.title |
A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine plus carboplatin in non-small cell lung cancer patients |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1158/1078-0432.CCR-07-4754 |
en |
pubs.issue |
13 |
en |
pubs.begin-page |
4213 |
en |
pubs.volume |
14 |
en |
dc.rights.holder |
Copyright: American Association for Cancer Research |
en |
dc.identifier.pmid |
18594002 |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000257377300026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.end-page |
4218 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
115605 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.record-created-at-source-date |
2012-05-25 |
en |