The contractile segment of the abneural limbus in the gecko cochlea is enriched in vimentin

Show simple item record Ganeshina, Olga en Kuznetsov, SA en Vorobiev, Mikhail en 2012-05-25T01:00:33Z en 2007-12-01 en
dc.identifier.citation CELL AND TISSUE RESEARCH 330(3):405-412 01 Dec 2007 en
dc.identifier.issn 0302-766X en
dc.identifier.uri en
dc.description.abstract Previously, we discovered a contractile segment within the cartilaginous abneural limbus of the gecko cochlea, the noncartilaginous abneural limbus (NAL, Ganeshina and Vorobyev, J Comp Neurol 461:539-547, 2003). Here, we demonstrate, by means of SDS-PAGE electrophoresis, the nanoLC-ESI-MSMS technique, immunoblotting, and immunocytochemistry, that the major cytoskeletal protein of the NAL cells is vimentin. Filamentous actin constitutes a minor component of the NAL contractile cell cytoskeleton. Our data indicate that the NAL represents a previously unknown specialization of connective tissue, characterized by the reduction of extracellular matrix and a hypertrophy of the vimentin-based intracellular cytoskeleton. The results are compatible with our hypothesis that the NAL is involved in an adaptation of the cochlear mechanics. en
dc.language English en
dc.publisher SPRINGER en
dc.relation.ispartofseries Cell and Tissue Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Cell Biology en
dc.subject intermediate filaments en
dc.subject contractile cells en
dc.subject cochlear mechanics en
dc.subject hearing en
dc.subject lizards en
dc.subject lacertilia en
dc.subject OUTER HAIR-CELLS en
dc.subject SPIRAL LIGAMENT en
dc.subject ACTIN-FILAMENTS en
dc.subject INTRACELLULAR CA2+ en
dc.subject SUPPORTING CELLS en
dc.subject HYALINE CELLS en
dc.title The contractile segment of the abneural limbus in the gecko cochlea is enriched in vimentin en
dc.type Journal Article en
dc.identifier.doi 10.1007/s00441-007-0475-6 en
pubs.issue 3 en
pubs.begin-page 405 en
pubs.volume 330 en
dc.rights.holder Copyright: SPRINGER en
dc.identifier.pmid 17922145 en en
pubs.end-page 412 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 222906 en Medical and Health Sciences en Optometry and Vision Science en
pubs.record-created-at-source-date 2012-05-25 en
pubs.dimensions-id 17922145 en

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