dc.contributor.author |
Ganeshina, Olga |
en |
dc.contributor.author |
Kuznetsov, SA |
en |
dc.contributor.author |
Vorobiev, Mikhail |
en |
dc.date.accessioned |
2012-05-25T01:00:33Z |
en |
dc.date.issued |
2007-12-01 |
en |
dc.identifier.citation |
CELL AND TISSUE RESEARCH 330(3):405-412 01 Dec 2007 |
en |
dc.identifier.issn |
0302-766X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18429 |
en |
dc.description.abstract |
Previously, we discovered a contractile segment within the cartilaginous abneural limbus of the gecko cochlea, the noncartilaginous abneural limbus (NAL, Ganeshina and Vorobyev, J Comp Neurol 461:539-547, 2003). Here, we demonstrate, by means of SDS-PAGE electrophoresis, the nanoLC-ESI-MSMS technique, immunoblotting, and immunocytochemistry, that the major cytoskeletal protein of the NAL cells is vimentin. Filamentous actin constitutes a minor component of the NAL contractile cell cytoskeleton. Our data indicate that the NAL represents a previously unknown specialization of connective tissue, characterized by the reduction of extracellular matrix and a hypertrophy of the vimentin-based intracellular cytoskeleton. The results are compatible with our hypothesis that the NAL is involved in an adaptation of the cochlear mechanics. |
en |
dc.language |
English |
en |
dc.publisher |
SPRINGER |
en |
dc.relation.ispartofseries |
Cell and Tissue Research |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0302-766X/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Science & Technology |
en |
dc.subject |
Life Sciences & Biomedicine |
en |
dc.subject |
Cell Biology |
en |
dc.subject |
intermediate filaments |
en |
dc.subject |
contractile cells |
en |
dc.subject |
cochlear mechanics |
en |
dc.subject |
hearing |
en |
dc.subject |
lizards |
en |
dc.subject |
lacertilia |
en |
dc.subject |
VERTEBRATE SMOOTH-MUSCLE |
en |
dc.subject |
LIVING ENDOTHELIAL-CELLS |
en |
dc.subject |
OUTER HAIR-CELLS |
en |
dc.subject |
INTERMEDIATE-FILAMENTS |
en |
dc.subject |
SPIRAL LIGAMENT |
en |
dc.subject |
ACTIN-FILAMENTS |
en |
dc.subject |
MECHANICAL-PROPERTIES |
en |
dc.subject |
INTRACELLULAR CA2+ |
en |
dc.subject |
SUPPORTING CELLS |
en |
dc.subject |
HYALINE CELLS |
en |
dc.title |
The contractile segment of the abneural limbus in the gecko cochlea is enriched in vimentin |
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dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1007/s00441-007-0475-6 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
405 |
en |
pubs.volume |
330 |
en |
dc.rights.holder |
Copyright: SPRINGER |
en |
dc.identifier.pmid |
17922145 |
en |
pubs.author-url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000250833200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e41486220adb198d0efde5a3b153e7d |
en |
pubs.end-page |
412 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
222906 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Optometry and Vision Science |
en |
pubs.record-created-at-source-date |
2012-05-25 |
en |
pubs.dimensions-id |
17922145 |
en |