Statistical issues in lifecourse epidemiology

Show simple item record De Stavola, BL en Nitsch, D en dos Santos Silva, I en McCormack, V en Hardy, R en Mann, V en Cole, T en Hofman, Paul en Leon, DA en 2012-05-28T01:16:44Z en 2006 en
dc.identifier.citation Am J Epidemiol 163(1):84-96 01 Jan 2006 en
dc.identifier.issn 0002-9262 en
dc.identifier.uri en
dc.description.abstract There is growing recognition that the risk of many diseases in later life, such as type 2 diabetes or breast cancer, is affected by adult as well as early-life variables, including those operating prior to conception and during the prenatal period. Most of these risk factors are correlated because of common biologic and/or social pathways, while some are intrinsically ordered over time. The study of how they jointly influence later (‘‘distal’’) disease outcomes is referred to as life course epidemiology. This area of research raises several issues relevant to the current debate on causal inference in epidemiology. The authors give a brief overview of the main analytical and practical problems and consider a range of modeling approaches, their differences determined by the degree with which associations present (or presumed) among the correlated explanatory variables are explicitly acknowledged. Standard multiple regression (i.e., conditional) models are compared with joint models where more than one outcome is specified. Issues arising from measurement error and missing data are addressed. Examples from two cohorts in the United Kingdom are used to illustrate alternative modeling strategies. The authors conclude that more than one analytical approach should be adopted to gain more insight into the underlying mechanisms. en
dc.publisher Johns Hopkins Bloomberg School of Public Health en
dc.relation.ispartofseries American Journal of Epidemiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Statistical issues in lifecourse epidemiology en
dc.type Journal Article en
dc.identifier.doi 10.1093/aje/kwj003 en
pubs.issue 1 en
pubs.begin-page 84 en
pubs.volume 163 en
dc.rights.holder Copyright: Johns Hopkins Bloomberg School of Public Health en
dc.identifier.pmid 16306313 en
pubs.end-page 96 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 69650 en Liggins Institute en Medical and Health Sciences en Population Health en Social & Community Health en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 16306313 en

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