dc.contributor.author |
Dean, Justin |
en |
dc.contributor.author |
George, Sherly |
en |
dc.contributor.author |
Naylor, Andrew |
en |
dc.contributor.author |
Mallard, EC |
en |
dc.contributor.author |
Gunn, Alistair |
en |
dc.contributor.author |
Bennet, Laura |
en |
dc.date.accessioned |
2012-05-28T02:29:01Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Neuropharmacology 55(2):166-174 Aug 2008 |
en |
dc.identifier.issn |
0028-3908 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18682 |
en |
dc.description.abstract |
We have previously shown that brief a2-adrenergic receptor blockade increased neuronal injury after severe hypoxia in preterm fetal sheep. We now examine whether infusion of an a2-adrenergic receptor agonist, clonidine, is neuroprotective. Preterm fetal sheep (70% gestation) received either saline-vehicle or clonidine at either 10 mg/kg/h (low-dose) or 100 mg/kg/h (high-dose) from 15 min until 4 h after 25 min of umbilical cord occlusion. Both low- and high-dose clonidine infusions after sham-occlusion were associated with transient EEG suppression but no neuronal loss. Low-dose but not high-dose clonidine infusions after umbilical cord occlusion were associated with a significant overall increase in numbers of surviving neurons after three days’ recovery. High-dose clonidine was associated with transient hyperglycemia and increased numbers of delayed electrographic seizures. These results provide further evidence that a2-adrenergic receptor activation shortly after perinatal hypoxia–ischemia can promote neural recovery, but highlight the complex dose–response of exogenous therapy. 2008 Elsevier Ltd. All rights |
en |
dc.publisher |
Elsevier |
en |
dc.relation.ispartofseries |
Neuropharmacology |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0028-3908/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Partial neuroprotection with low dose infusion of the 2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.neuropharm.2008.05.009 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
166 |
en |
pubs.volume |
55 |
en |
dc.rights.holder |
Copyright: Elsevier |
en |
dc.identifier.pmid |
18572205 |
en |
pubs.end-page |
174 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
79684 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Physiology Division |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18572205 |
en |