Partial neuroprotection with low dose infusion of the 2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep.

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dc.contributor.author Dean, Justin en
dc.contributor.author George, Sherly en
dc.contributor.author Naylor, Andrew en
dc.contributor.author Mallard, EC en
dc.contributor.author Gunn, Alistair en
dc.contributor.author Bennet, Laura en
dc.date.accessioned 2012-05-28T02:29:01Z en
dc.date.issued 2008 en
dc.identifier.citation Neuropharmacology 55(2):166-174 Aug 2008 en
dc.identifier.issn 0028-3908 en
dc.identifier.uri http://hdl.handle.net/2292/18682 en
dc.description.abstract We have previously shown that brief a2-adrenergic receptor blockade increased neuronal injury after severe hypoxia in preterm fetal sheep. We now examine whether infusion of an a2-adrenergic receptor agonist, clonidine, is neuroprotective. Preterm fetal sheep (70% gestation) received either saline-vehicle or clonidine at either 10 mg/kg/h (low-dose) or 100 mg/kg/h (high-dose) from 15 min until 4 h after 25 min of umbilical cord occlusion. Both low- and high-dose clonidine infusions after sham-occlusion were associated with transient EEG suppression but no neuronal loss. Low-dose but not high-dose clonidine infusions after umbilical cord occlusion were associated with a significant overall increase in numbers of surviving neurons after three days’ recovery. High-dose clonidine was associated with transient hyperglycemia and increased numbers of delayed electrographic seizures. These results provide further evidence that a2-adrenergic receptor activation shortly after perinatal hypoxia–ischemia can promote neural recovery, but highlight the complex dose–response of exogenous therapy. 2008 Elsevier Ltd. All rights en
dc.publisher Elsevier en
dc.relation.ispartofseries Neuropharmacology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from: http://www.sherpa.ac.uk/romeo/issn/0028-3908/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Partial neuroprotection with low dose infusion of the 2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.neuropharm.2008.05.009 en
pubs.issue 2 en
pubs.begin-page 166 en
pubs.volume 55 en
dc.rights.holder Copyright: Elsevier en
dc.identifier.pmid 18572205 en
pubs.end-page 174 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 79684 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Physiology Division en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18572205 en


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