Periconceptional events perturb postnatal growth regulation in sheep

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dc.contributor.author Jaquiery, Anne en
dc.contributor.author Oliver, MH en
dc.contributor.author Bloomfield, Francis en
dc.contributor.author Harding, JE en
dc.date.accessioned 2012-06-06T00:50:09Z en
dc.date.issued 2011 en
dc.identifier.citation Pediatric Research 70(3):261-266 2011 en
dc.identifier.issn 0031-3998 en
dc.identifier.uri http://hdl.handle.net/2292/18885 en
dc.description.abstract Periconceptional undernutrition and twin conception alter intrauterine growth and metabolism and are associated with later adverse metabolic outcomes. The contribution of postnatal growth to these outcomes is less well defined. We investigated whether maternal periconceptional undernutrition or twin conception altered postnatal growth regulation in ways that could lead to metabolic disease. Single and twin offspring of ewes undernourished (UN) from 61 d before until 30 d after mating, fed to achieve and maintain 10 –15% weight loss (UN), were compared with offspring of maintenance-fed controls (N). At 2 h and 1, 6, and 12 wk after birth, lambs were weighed and plasma hormone and metabolite concentrations analyzed. Milk intake, measured by deuterium oxide dilution, was inversely related to birth weight only in N singles, although twins had the greatest postnatal growth velocity. Positive associations were seen between milk intake, growth velocity, and leptin concentrations in N, but not UN, offspring. We conclude that periconceptional undernutrition alters the relationships between regulators of postnatal growth, including nutrient intake and key hormonal axes, in both singles and twins without affecting size at birth or postnatal growth velocity. Dissociation of growth from its key regulators is one possible mechanism underlying adverse metabolic outcomes after periconceptional undernutrition. en
dc.publisher International Pediatric Research Foundation, Inc. en
dc.relation.ispartofseries Pediatric Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Periconceptional events perturb postnatal growth regulation in sheep en
dc.type Journal Article en
dc.identifier.doi 10.1203/PDR.0b013e3182242deb en
pubs.issue 3 en
pubs.begin-page 261 en
pubs.volume 70 en
dc.rights.holder Copyright: International Pediatric Research Foundation, Inc. en
pubs.end-page 266 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 238014 en
pubs.org-id Liggins Institute en
pubs.org-id LiFePATH en
pubs.record-created-at-source-date 2011-11-07 en


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