Abstract:
Hypoxia occurs in most human tumors and is associated with diseaseprogression, resistance to conventional therapies and poor patientoutcome. Hypoxia can up-regulate HER1 by several known mechanisms,including increased mRNA translation (Franovic et al., PNAS,2007;104:13092)and delayed receptor endocytosis (Wang et al., Nat Med.,2009;15:319)