dc.contributor.author |
Selak, Vanessa |
en |
dc.contributor.author |
Elley, Carolyn |
en |
dc.contributor.author |
Wells, Linda |
en |
dc.contributor.author |
Rodgers, A |
en |
dc.contributor.author |
Sharpe, N |
en |
dc.date.accessioned |
2012-06-12T02:13:52Z |
en |
dc.date.issued |
2010 |
en |
dc.identifier.citation |
Journal of Primary Health Care 2(2):92-99 2010 |
en |
dc.identifier.issn |
1172-6156 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18936 |
en |
dc.description.abstract |
ABSTRACT Aimim: To assess benefit versus harm of aspirin for cardiovascular disease (CVD) primary prevention by age group, gender and risk category and to interpret these results in light of current New Zealand CVD risk assessment and management guidelines. Methodethodethodethodethods: Rates of benefit (avoided vascular events) and harm (additional major extracranial bleeds) for each gender and age group were calculated from data from the six randomised controlled trials included in the Anti-Thrombotic Trialists, (ATT) Collaboration meta-analysis. These rates were applied to CVD risk categories to calculate the net benefit or net harm likely to occur from the use of aspirin in primary prevention of CVD as monotherapy and when added to lipid and blood pressure-lowering therapies. Resultultults: Benefits of aspirin monotherapy outweigh the harms for both men and women aged up to 80 years with calculated five-year CVD risk >15% in primary prevention. Harm may outweigh benefit for primary prevention for those over 80 years. For men 70-79 years the benefit of aspirin in primary prevention is marginal when added to lipid and blood pressure-lowering therapies. Discucussioion: The recent ATT Collaboration meta-analysis has raised doubts about the relative safety of aspirin in primary prevention of CVD. However, modelling by risk category and age group suggests that current guidelines are justified in recommending aspirin for primary prevention of CVD in those with five-year CVD risk e15% up to the age of 80 years. For men 70-79, consider lipid and blood pressure-lowering therapies first then reassess whether aspirin adds additional net benefit. KEYWORDS: Aspirin; primary prevention; cardiovascular disease; cardiovascular risk |
en |
dc.publisher |
The Royal New Zealand College of General Practitioners |
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dc.relation.ispartofseries |
Journal of Primary Health Care |
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dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
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dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
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dc.title |
Aspirin for primary prevention: yes or no? |
en |
dc.type |
Journal Article |
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pubs.issue |
2 |
en |
pubs.begin-page |
92 |
en |
pubs.volume |
2 |
en |
dc.rights.holder |
Copyright: The Royal New Zealand College of General Practitioners |
en |
dc.identifier.pmid |
20690297 |
en |
pubs.author-url |
https://www-rnzcgp-org-nz.ezproxy.auckland.ac.nz:9443/assets/documents/Publications/JPHC/June-2010/JPHCOSPSelakJune10.pdf |
en |
pubs.end-page |
99 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
102538 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Population Health |
en |
pubs.org-id |
Epidemiology & Biostatistics |
en |
pubs.org-id |
Gen.Practice& Primary Hlthcare |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
20690297 |
en |