Anti-herpes simplex virus activities of two novel disulphated cyclitols

Show simple item record Ekblad, M en Bergström, T en Banwell, MG en Bonnet, Muriel en Renner, J en Ferro, V en Trybala, E en 2012-06-12T20:15:04Z en 2006 en
dc.identifier.citation Antiviral Chemistry and Chemotherapy 17:97-106 2006 en
dc.identifier.issn 0956-3202 en
dc.identifier.uri en
dc.description.abstract By screening a library of sulphated compounds of low molecular weight, we have found that several cyclitol derivatives, each modified with two sulphate groups in addition to pyrrole and various aromatic moieties, inhibited infectivity of herpes simplex virus (HSV) at concentrations approximately 100 times lower than those toxic for cultured cells. These disulphated cyclitols interfered with HSV-1 attachment to cells, and efficiently reduced the cell-to-cell spread of the virus. This effect is most likely due to their low molecular weight and associated with the compounds’ capability to access the narrow intercellular spaces. Furthermore, these disulphated cyclitols also inactivated infectivity of HSV. However, the virus-inactivating activities of these compounds were to some extent diminished in the presence of human cervical secretions or other protein-rich solutions suggesting that disulphated cyclitols may have some features of surfactant-type virucides. In conclusion, this new class of anti-HSV compounds offers potential for further development. en
dc.publisher International Medical Press en
dc.relation.ispartofseries Antiviral Chemistry and Chemotherapy en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.title Anti-herpes simplex virus activities of two novel disulphated cyclitols en
dc.type Journal Article en
pubs.begin-page 97 en
pubs.volume 17 en
dc.rights.holder Copyright: International Medical Press en en
pubs.end-page 106 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 299408 en
pubs.record-created-at-source-date 2012-02-21 en

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