dc.contributor.author |
Brooke, Darby |
en |
dc.contributor.author |
Phiasivongsa, P |
en |
dc.contributor.author |
Denny, WA |
en |
dc.contributor.author |
Gamage, S |
en |
dc.contributor.author |
Bearss, DJ |
en |
dc.contributor.author |
Vankayalapati, H |
en |
dc.contributor.author |
Redkar, SG |
en |
dc.contributor.other |
Denny, WA |
en |
dc.contributor.other |
Gamage, SA |
en |
dc.coverage.spatial |
United States |
en |
dc.date.accessioned |
2012-06-12T20:27:44Z |
en |
dc.date.issued |
2009 |
en |
dc.date.submitted |
2007-12-18 |
en |
dc.identifier.citation |
Patent/Trademark number: US Patent 7,790,746 (USA). Application number: PCT/US2008/079486. Associated authors: Denny WA, Gamage SA. Status: Published. Application date: 2008. Awarded date: 16 Apr 2009 |
en |
dc.identifier.govdoc |
US 7790746 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/18946 |
en |
dc.description.abstract |
(EN)Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders. (FR)Cette invention concerne des dérivés de quinoline, en particulier des dérivés de 4-anilinoquinoline. Ces dérivés de quinoline peuvent être utilisés dans la modulation de la méthylation de l'ADN, par exemple dans l'inhibition effective de la méthylation de la cytosine en position C-5, par exemple par une inhibition sélective de l'ADN méthyltransférase DNMT1. L'invention concerne par ailleurs des procédés permettant de synthétiser plusieurs dérivés de 4-anilinoquinoline et de moduler la méthylation de l'ADN. L'invention concerne également des procédés permettant de formuler et d'administrer ces composés ou ces compositions pour traiter des pathologies comme le cancer et les troubles hématologiques. |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Quinoline derivatives for modulating DNA methylation. |
en |
dc.type |
Patent |
en |
dc.rights.holder |
Copyright: The Authors |
en |
pubs.author-url |
http://www.patentlens.net/patentlens/patent/US_7790746/en/ |
en |
pubs.patent-status |
Granted |
en |
pubs.publication-status |
Published |
en |
pubs.start-date |
2010 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
320580 |
en |
pubs.number |
11959181 |
en |
pubs.record-created-at-source-date |
2012-03-14 |
en |