Effect of litter size and birth weight on naturally occurring myopia in the Labrador retriever

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dc.contributor.author Phillips, John en
dc.contributor.author Black, Joanna en
dc.contributor.author Browning, Sharon en
dc.contributor.author Collins, Andrew en
dc.coverage.spatial Portoroz, Slovenia en
dc.date.accessioned 2012-06-21T01:59:57Z en
dc.date.issued 2008-10-01 en
dc.identifier.citation 2008 European Association for Vision and Eye Research Conference (EVER), Portoroz, Slovenia, 01 Oct 2008 - 04 Oct 2008. en
dc.identifier.uri http://hdl.handle.net/2292/19093 en
dc.description.abstract Purpose To evaluate early environmental influences (e.g. litter size, birth weight, birth season) on adult refractive error in dogs. A previous familial aggregation analysis has shown that the distribution of refractive error in a large family of pedigree Labrador Retrievers has a significant genetic component, but that litter size and other residual/environmental factors also have significant effects. Methods Refractive error was measured by cycloplegic retinoscopy in both eyes of 166 dogs, 1-8 years of age and free of ocular pathology, from a large family of pedigree Labrador Retrievers. All dogs originated from the same breeding colony. The early records of these dogs included information on birth weight, maternal litter cohort, litter size and neonatal weight gain, measured daily for the first 6 weeks. These factors were analyzed to investigate their effect on adult refractive error. Results The average adult spherical equivalent refraction (SER) was -0.44D (-5.38D to +1.65D, n = 166): 35% were myopic (SER ≤ -0.50D), 58% emmetropic (SER = -0.49 to +0.99) and 7% hyperopic (SER ≥ +1.00D). Mean birth weight was 421±57g. Higher birth weight was weakly (R=0.3) correlated with more hyperopic adult refractions. Relative to large litters (≥ 7), dogs from small litters (< 7) gained more weight within the first 6 weeks of life and were on average 0.43D more myopic. Conclusion The dog provides a unique model for studying a wide range of environmental influences on the development of naturally occurring, high prevalence, low degree myopia. en
dc.relation.ispartof 2008 European Association for Vision and Eye Research Conference (EVER) en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Effect of litter size and birth weight on naturally occurring myopia in the Labrador retriever en
dc.type Conference Item en
dc.identifier.doi 10.1111/j.1755-3768.2008.455.x en
pubs.issue Issue Supplement s243 en
pubs.volume 82 en
dc.rights.holder Copyright: Acta Ophthalmologica en
pubs.finish-date 2008-10-04 en
pubs.start-date 2008-10-01 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Other en
pubs.elements-id 80309 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Optometry and Vision Science en
pubs.org-id Science en
pubs.org-id Statistics en
pubs.record-created-at-source-date 2010-09-01 en

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