Differing causes of pregnancy loss in type 1 and type 2 diabetes

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dc.contributor.author Cundy, Timothy en
dc.contributor.author Gamble, Gregory en
dc.contributor.author Neale, L en
dc.contributor.author Elder, R en
dc.contributor.author McPherson, P en
dc.contributor.author Henley, P en
dc.contributor.author Rowan, J en
dc.date.accessioned 2012-06-28T01:37:54Z en
dc.date.issued 2007 en
dc.identifier.citation Diabetes Care 30(10):2603-2607 Oct 2007 en
dc.identifier.uri http://hdl.handle.net/2292/19207 en
dc.description.abstract OBJECTIVE — Women with type 2 and type 1 diabetes have differing risk factors for pregnancy loss. We compared the rates and causes of pregnancy loss in women with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS — We utilized prospectively collected data on all pregnancies in a 20-year period (1986 –2005) from a single center with a high prevalence of type 2 diabetes. Pregnancy losses included terminations for medical reasons and deaths up to 1 month postpartum but not spontaneous pregnancy losses 20 weeks’ gestation. RESULTS — There were 870 pregnancies in women with known diabetes (330 with type 1 and 540 with type 2 diabetes) and 325 in women with diabetes diagnosed in pregnancy but persisting postpartum (97% type 2 diabetes). The rate of pregnancy loss was similar in type 1 and type 2 diabetes (2.6 vs. 3.7%, P 0.39), but the causes of pregnancy loss differed. In type 1 diabetes 75% were attributable to major congenital anomalies or prematurity; in type 2 diabetes 75% were attributable to stillbirth or chorioamnionitis (P 0.017). Women with type 2 and type 1 diabetes had similar A1C at presentation and near term, but the former were older (P 0.001) and more obese (P 0.0001). CONCLUSIONS — There are significant differences in the main causes of pregnancy loss in women with type 1 and type 2 diabetes. The higher rates of stillbirth in women with type 2 diabetes, suggest that other features, such as obesity, contribute significantly to pregnancy losses en
dc.publisher American Diabetes Association en
dc.relation.ispartofseries Diabetes Care en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Differing causes of pregnancy loss in type 1 and type 2 diabetes en
dc.type Journal Article en
dc.identifier.doi 10.2337/dc07-0555 en
pubs.begin-page 2603 en
pubs.volume 30 en
dc.rights.holder Copyright: American Diabetes Association en
dc.identifier.pmid 17586739 en
pubs.end-page 2607 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 77197 en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Medicine Department en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 17586739 en

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