dc.contributor.author |
Cundy, Timothy |
en |
dc.contributor.author |
Gamble, Gregory |
en |
dc.contributor.author |
Neale, L |
en |
dc.contributor.author |
Elder, R |
en |
dc.contributor.author |
McPherson, P |
en |
dc.contributor.author |
Henley, P |
en |
dc.contributor.author |
Rowan, J |
en |
dc.date.accessioned |
2012-06-28T01:37:54Z |
en |
dc.date.issued |
2007 |
en |
dc.identifier.citation |
Diabetes Care 30(10):2603-2607 Oct 2007 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/19207 |
en |
dc.description.abstract |
OBJECTIVE — Women with type 2 and type 1 diabetes have differing risk factors for pregnancy loss. We compared the rates and causes of pregnancy loss in women with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS — We utilized prospectively collected data on all pregnancies in a 20-year period (1986 –2005) from a single center with a high prevalence of type 2 diabetes. Pregnancy losses included terminations for medical reasons and deaths up to 1 month postpartum but not spontaneous pregnancy losses 20 weeks’ gestation. RESULTS — There were 870 pregnancies in women with known diabetes (330 with type 1 and 540 with type 2 diabetes) and 325 in women with diabetes diagnosed in pregnancy but persisting postpartum (97% type 2 diabetes). The rate of pregnancy loss was similar in type 1 and type 2 diabetes (2.6 vs. 3.7%, P 0.39), but the causes of pregnancy loss differed. In type 1 diabetes 75% were attributable to major congenital anomalies or prematurity; in type 2 diabetes 75% were attributable to stillbirth or chorioamnionitis (P 0.017). Women with type 2 and type 1 diabetes had similar A1C at presentation and near term, but the former were older (P 0.001) and more obese (P 0.0001). CONCLUSIONS — There are significant differences in the main causes of pregnancy loss in women with type 1 and type 2 diabetes. The higher rates of stillbirth in women with type 2 diabetes, suggest that other features, such as obesity, contribute significantly to pregnancy losses |
en |
dc.publisher |
American Diabetes Association |
en |
dc.relation.ispartofseries |
Diabetes Care |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Differing causes of pregnancy loss in type 1 and type 2 diabetes |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.2337/dc07-0555 |
en |
pubs.begin-page |
2603 |
en |
pubs.volume |
30 |
en |
dc.rights.holder |
Copyright: American Diabetes Association |
en |
dc.identifier.pmid |
17586739 |
en |
pubs.end-page |
2607 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
77197 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Medicine Department |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
17586739 |
en |