Acanthamoeba keratitis and contact lens wear

Show simple item record Lindsay, RG en Watters, G en Johnson, R en Ormonde, Susan en Snibson, GR en 2012-07-02T23:35:00Z en 2007-09-01 en
dc.identifier.citation CLINICAL AND EXPERIMENTAL OPTOMETRY 90(5):351-360 01 Sep 2007 en
dc.identifier.issn 0816-4622 en
dc.identifier.uri en
dc.description.abstract Acanthamoeba keratitis is a rare but serious complication of contact lens wear that may cause severe visual loss. The clinical picture is usually characterised by severe pain, sometimes disproportionate to the signs, with an early superficial keratitis that is often misdiagnosed as herpes simplex virus (HSV) keratitis. Advanced stages of the infection are usually characterised by central corneal epithelial loss and marked stromal opacification with subsequent loss of vision. In this paper, six cases of contact lens-related Acanthamoeba keratitis that occurred in Australia and New Zealand over a three-year period are described. Three of the patients were disposable soft lens wearers, two were hybrid lens wearers and one was a rigid gas permeable lens wearer. For all six cases, the risk factors for Acanthamoeba keratitis were contact lens wear with inappropriate or ineffective lens maintenance and exposure of the contact lenses to tap or other sources of water. All six patients responded well to medical therapy that involved topical use of appropriate therapeutic agents, most commonly polyhexamethylene biguanide and propamidine isethionate, although two of the patients also subsequently underwent deep lamellar keratoplasty due to residual corneal surface irregularity and stromal scarring. Despite the significant advances that have been made in the medical therapy of Acanthamoeba keratitis over the past 10 years, prevention remains the best treatment and patients who wear contact lenses must be thoroughly educated about the proper use and care of the lenses. In particular, exposure of the contact lenses to tap water or other sources of water should be avoided. en
dc.language English en
dc.publisher Blackwell Publishing Ltd en
dc.relation.ispartofseries Clinical and Experimental Optometry en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject Science & Technology en
dc.subject Life Sciences & Biomedicine en
dc.subject Ophthalmology en
dc.subject Acanthamoeba keratitis en
dc.subject contact lenses en
dc.subject EARLY-DIAGNOSIS en
dc.subject RISK en
dc.subject CONTAMINATION en
dc.subject EPIDEMIOLOGY en
dc.subject PROPAMIDINE en
dc.subject CASTELLANII en
dc.subject MANAGEMENT en
dc.subject INFECTION en
dc.title Acanthamoeba keratitis and contact lens wear en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1444-0938.2007.00172.x en
pubs.issue 5 en
pubs.begin-page 351 en
pubs.volume 90 en
dc.rights.holder Copyright: Blackwell Publishing Ltd en
dc.identifier.pmid 17697181 en
pubs.end-page 360 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 113978 en Medical and Health Sciences en School of Medicine en Ophthalmology Department en
pubs.record-created-at-source-date 2012-07-03 en
pubs.dimensions-id 17697181 en

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